Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 305-053-6 | CAS number: 94333-72-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Citronellol
- EC Number:
- 203-375-0
- EC Name:
- Citronellol
- Cas Number:
- 106-22-9
- Molecular formula:
- C10H20O
- IUPAC Name:
- 3,7-dimethyloct-6-en-1-ol
- Reference substance name:
- Geraniol
- EC Number:
- 203-377-1
- EC Name:
- Geraniol
- Cas Number:
- 106-24-1
- Molecular formula:
- C10H18O
- IUPAC Name:
- (E)-3,7-dimethylocta-2,6-dien-1-ol
- Reference substance name:
- (E)-6,10-dimethylundeca-3,9-dien-2-one
- Cas Number:
- 19870-49-6
- Molecular formula:
- C12H20O
- IUPAC Name:
- (E)-6,10-dimethylundeca-3,9-dien-2-one
- Reference substance name:
- Dipentene
- EC Number:
- 205-341-0
- EC Name:
- Dipentene
- Cas Number:
- 138-86-3
- Molecular formula:
- C10H16
- IUPAC Name:
- 1-methyl-4-(prop-1-en-2-yl)cyclohex-1-ene
- Reference substance name:
- Linalool
- EC Number:
- 201-134-4
- EC Name:
- Linalool
- Cas Number:
- 78-70-6
- Molecular formula:
- C10H18O
- IUPAC Name:
- 3,7-dimethylocta-1,6-dien-3-ol
- Reference substance name:
- (±)-(1α,2β,5α)-5-methyl-2-(1-methylvinyl)cyclohexan-1-ol
- EC Number:
- 256-557-7
- EC Name:
- (±)-(1α,2β,5α)-5-methyl-2-(1-methylvinyl)cyclohexan-1-ol
- Cas Number:
- 50373-36-9
- Molecular formula:
- C10H18O
- IUPAC Name:
- rel-(1R,2S,5R)-5-methyl-2-(prop-1-en-2-yl)cyclohexanol
- Reference substance name:
- (1α,2β,4β)-1-methyl-2,4-bis(methylvinyl)-1-vinylcyclohexane
- EC Number:
- 251-713-0
- EC Name:
- (1α,2β,4β)-1-methyl-2,4-bis(methylvinyl)-1-vinylcyclohexane
- Cas Number:
- 33880-83-0
- Molecular formula:
- C15H24
- IUPAC Name:
- rel-(1R,2R,4S)-1-methyl-2,4-di(prop-1-en-2-yl)-1-vinylcyclohexane
- Reference substance name:
- (1E,6E)-8-isopropyl-1-methyl-5-methylenecyclodeca-1,6-diene
- Cas Number:
- 105453-16-5
- Molecular formula:
- C15H24
- IUPAC Name:
- (1E,6E)-8-isopropyl-1-methyl-5-methylenecyclodeca-1,6-diene
- Reference substance name:
- rel-(1R,4aR,8aS)-1-isopropyl-4,7-dimethyl-1,2,4a,5,6,8a-hexahydronaphthalene
- Cas Number:
- 31983-22-9
- Molecular formula:
- C15H24
- IUPAC Name:
- rel-(1R,4aR,8aS)-1-isopropyl-4,7-dimethyl-1,2,4a,5,6,8a-hexahydronaphthalene
- Reference substance name:
- rel-(1R,4aS,8aS)-1-isopropyl-7-methyl-4-methylene-1,2,3,4,4a,5,6,8aoctahydronaphthalene
- Cas Number:
- 39029-41-9
- Molecular formula:
- C15H24
- IUPAC Name:
- rel-(1R,4aS,8aS)-1-isopropyl-7-methyl-4-methylene-1,2,3,4,4a,5,6,8aoctahydronaphthalene
- Reference substance name:
- rel-(1R,8aS)-1-isopropyl-4,7-dimethyl-1,2,3,5,6,8ahexahydronaphthalene
- Cas Number:
- 60305-17-1
- Molecular formula:
- C15H24
- IUPAC Name:
- rel-(1R,8aS)-1-isopropyl-4,7-dimethyl-1,2,3,5,6,8ahexahydronaphthalene
- Reference substance name:
- rel-2-((1R,3S,4S)-4-methyl-3-(prop-1-en-2-yl)-4-vinylcyclohexyl)propan-2-ol
- Cas Number:
- 23811-48-5
- Molecular formula:
- C15H26O
- IUPAC Name:
- rel-2-((1R,3S,4S)-4-methyl-3-(prop-1-en-2-yl)-4-vinylcyclohexyl)propan-2-ol
- Reference substance name:
- 5,9-dimethyl-2-(6-methylhept-5-en-2-yl)deca-2,8-dienal
- Cas Number:
- 82451-80-7
- Molecular formula:
- C20H34O
- IUPAC Name:
- 5,9-dimethyl-2-(6-methylhept-5-en-2-yl)deca-2,8-dienal
- Reference substance name:
- Likely oxygenated constituent
- IUPAC Name:
- Likely oxygenated constituent
- Reference substance name:
- Unknown Impurities
- IUPAC Name:
- Unknown Impurities
- Test material form:
- liquid
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Constituent 5
Constituent 6
Constituent 7
Constituent 8
Constituent 9
Constituent 10
Constituent 11
Constituent 12
Constituent 13
Constituent 14
Constituent 15
- Specific details on test material used for the study:
- Test Item: Baccartol Crude
Batch Number: VE00364716
Purity: Not applicable - complex mixture
Appearance: yellow viscous liquid
Expiry date: 2017-04-02
Recommended storage: Keep container tightly closed in a dry and well-ventilated place at ambient temperature (10 - 30 °C) protected from light.
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- At the start of the exposure and at renewal (0 and 24 hours), samples were taken from the freshly prepared WAFs and analyzed.
At renewal and at the end of the exposure (24 and 48 hours), samples of the 24-hour old media were taken directly from the test vessels and analyzed. Samples were analyzed immediately following sampling.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Five Water Accommodated Fractions (WAF) of the test item were individually prepared at loading levels of 6.25 - 12.5 - 25.0 - 50.0 - 100 mg/L in a geometric series with a separation factor of 2. For each loading level, an appropriate volume of the test item (relative density: 0.8905 (D20/4) was taken into account) was placed by a positive displacement pipette onto the water surface.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Test system: Daphnia magna STRAUS (Clone 5)
Reason for the selection of the test system: Daphnia magna is the preferred species in accordance with the test guidelines and is bred at the test facility.
Origin: Institut für Wasser-, Boden- und Lufthygiene (WaBoLu), 14195 Berlin, Germany
Breeder: Noack Laboratorien GmbH, Käthe-Paulus-Str. 1, 31157 Sarstedt, Germany
Culture: In glass vessels (2 - 3 L capacity) with approximately 1.8 L culture medium, at 20 ± 2 °C, in an incubator, 16 hours illumination, light intensity of max. 1500 lx
Culture medium: Elendt M4, according to OECD 202, Annex 3 (2004), modified to a total hardness of 160 to 180 mg CaC03/L, is used.
Culture feeding: The culture daphnids are fed at least 5 times per week ad libitum with a mix of unicellular green algae, e.g. Pseudokirchneriella subcapitata and Desmodesmus subspicatus, with an algae cell density of > 106cells/mL. The algae are cultured at the test facility.
Origin of the food algae: Sammlung von Algenkulturen (SAG), Pflanzenphysiologisches Institut der Universität Göttingen, Nikolausberger Weg 18, 37073 Göttingen, Germany
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
Test conditions
- Test temperature:
- 18-22 °C, constant within ± 1 °C
- Nominal and measured concentrations:
- Range finding (nominal): 1, 10 and 100 mg/L
Definitive test (nominal): 6.25 - 12.5 - 25.0 - 50.0 -100 mg/L in a geometric series with a separation factor of 2.
Definitive test (geonetric mean measured): 3.10, 4.34, 11.1, 32.7 and 69.6 mg/L - Details on test conditions:
- Test method: The study was performed with a semi-static test design, since the measured concentrations of the test item were not within the required range of ± 20% of the nominal values during the non-GLP preliminary range finding test. Due to the volatility of the test item, the study was performed in a closed system without headspace, to reduce contact with air and losses of the test item by evaporation.
Test vessels / volume: Sealed clear glass flasks (conical shoulder bottles with a narrow neck, 3.7 (ID) x 8 (H) cm) with glass stoppers were used. A test volume of approximately 60 mL was provided in each test vessel, when filled up to the top with the test solutions without any headspace.
Number of daphnids and replicates: 20 daphnids, divided into 4 replicates, each with 5 daphnids, were used per WAF and control.
Age of the daphnids at the start of the exposure: Less than 24 hours old daphnids from a healthy stock were used for the study. Juvenile daphnids were removed from the culture vessels at the latest 24 hours before the start of the exposure and discarded. The juveniles born within the following period of max. 24 hours preceding the exposure were used for the test. No first brood progeny was used for the test.
Acclimatization: Acclimatization of the daphnids was not necessary, because the dilution water was equivalent to the culture medium.
Application: The test vessels were filled up to the top with the test solutions. The daphnids were inserted with a small amount of dilution water (start of the exposure) or test solution (water renewal) by pipette. Thereafter, the test vessels were closed immediately with glass stoppers. There was no headspace in the test vessels.
Illumination (target): Diffuse light, light intensity of max. 1500 lx
Photoperiod (target): 16/8 hours light/dark cycle
Feeding: The daphnids were not fed during the study. - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate p.a. (Sigma)
Results and discussion
Effect concentrations
- Duration:
- 48 h
- Dose descriptor:
- EL50
- Effect conc.:
- 11.9 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: (95% confidence limits: 10.8 - 12.7 mg/L)
- Results with reference substance (positive control):
- The percentage of immobility for the reference item potassium dichromate (Sigma-Aldrich, batch number MKBV090ÛV, purity 99.0%, CAS RN 7778-50-9) was determined after 24 hours from 2017-02-16 to 2017-02-17. EC50 = 2.00 mg/L (95% CL 1.80 -2.28 mg/L)
Any other information on results incl. tables
Validity Criteria
The study was performed according to OECD Guideline 202 (2004). The validity criteria were fulfilled:
• In the control group, no daphnids were immobilized or showed any signs of disease or stress, e.g. discoloration or unusual behavior such as trapping on the surface of the water, during the 48-hour test period (required: not more than 10% of the daphnids in the control).
• The dissolved O2 concentration in the 24-hour old media at the end of the exposure intervals was 2 6.48 mg/L (required: 2 3 mg/L at the test end of the exposure intervals) in the test vessels of all tested WAFs and the control.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Based on the nominal loadings of the test item, the 48 hour-EL50 for Daphnia magna was 11.9 mg/L (95% confidence limits: 10.8 - 12.7 mg/L).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.