Registration Dossier
Registration Dossier
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EC number: 301-097-5 | CAS number: 93981-14-7
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Although there are some differing trends observed for the test data, there is no significant evidence for degradation of the test substance over the 7 day period of the study.
Key value for chemical safety assessment
Additional information
The hydrolysis potential of the registered substance was determined in accordance with the OECD Guideline for Testing of Chemicals 111. Recoveries at ambient temperature and at 50°C were investigated (see 'Hydrolysis_key study_50°C' for the results of the 50°C investigation). For all pH's, the recovery at 50°C was greater than that at ambient temperature (22.4°C) which was unexpected. Possible hydrolysis/reaction products that may be expected from the test substance were suggested by the sponsor (toluene sulphonic acid and the tosyl salt ester with triethanolamine) and the specific molecular weights of these species were examined but a conclusion was made that, at the concentrations analysed, there was no evidence of the species being present at any significant level. To check for further evidence of degradation, a further timepoint was analysed after approximately 6-7 days. High recoveries were observed versus theory for the intial timepoints, especially at pH 7 and pH 9. The reason for this is not known. Although there are some differing trends observed for the test data, there is no significant evidence for degradation of the test substance over the 7 day period of the study. In addition, a study was also conducted on the structurally similar substance 6-[Methyl(phenylsulphonyl)amino]hexanoic acid, compound with 2, 2', 2''-nitrilotriethanol (1:1) (N-methyl salt). The N-methyl salt also demonstrated no potential for hydrolysis.
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