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EC number: 258-110-1 | CAS number: 52697-38-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The test substance is not irritating to skin or eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- HC:NZW Albino Rabbits
Source: : Interfauna UK Ltd
Food: ssniff K 4
Supplier: sniff Spezialdiaten GmbH, Soest/Westfal
Water: Tap water
Food 100 to 120 g per animal per day; once per day in the morning
water ad libitum
Single housing
Weight: 3.1 to 3.3 kg
ENVIRONMENTAL CONDITIONS
- Temperature: 20±3°C
- Humidity: approx. 50 %
- Lighting time: 12 hours daily
In-life date: 18. Oct to 25. Oct. 1988 - Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Remarks:
- to form a paste
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 500 mg on 6x6 cm2 plaster
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- up to 7 d
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Preparation: about 24h before the start of the study the hair in the dorsal region on the body was removed with an electric clipped and shaved over an area of 6 cm x 6 cm
- Area of exposure: shaved skin 6 cm2
- Type of wrap if used: Fixomull-Stretch as elastic bandage
REMOVAL OF TEST SUBSTANCE
- Time after start of exposure: 4 hours
SCORING SYSTEM: according to the score of Draize - Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No signs of systemic toxicity were observed during the observation period
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In the experimental conditions described by OECD guideline 404 for evaluation of the acute dermal irritation / corrosivity of the substance Disperse Violet 93:1 is detemined to be not irritating to the skin.
- Executive summary:
About 24 hours before the start of the study the hair in the dorsal region of the body of 3 rabbits was removed with an electric clipper over an area of about 36 cm². Only animals with intact skin were used.
Each animal was treated with 0.5 g Disperse Violet 93:1 pasted with water. The substance was applied over the whole surface of a 6x6 cm² plaster. The plaster was fixed to the prepared skin area and then covered with a semi-occlusive bandage.
The exposure period was 4 hours. After the exposure period all remnants of the test substance were carefully removed from the skin with water.
Examinations of the skin took place after 60 minutes as well as 24, 48 and 72 hours and 7 days after removal of the patches.
Erythema, eschar formation and oedema were evaluated numerically according to the score of DRAIZE. All other changes of the skin were recorded.
No signs of irritation occurred during the whole study.
Testing of Disperse Violet 93:1 for primary dermal irritation in the rabbit showed, that the substance is not irritating to skin.
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- Jan. 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- NZW Albino Rabbits
Source: Lippische Versuchstierzucht, Hagemann GmbH & Co. KG, Extertal
Food: mümmel Z
Supplier: sniff Spezialdiaten GmbH, Soest/Westfal
Water: Tap water
Food 100 to 120 g per animal per day; once per day in the morning
water ad libitum
Single housing
Weight: mean 2.2 kg
Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature: 16-18°C
- Humidity: approx. 40 %
- Lighting time: 12 hours daily - Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Remarks:
- to form a paste
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 500 mg
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- up to 8 days
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Preparation: about 24h before the start of the study the hair in the dorsal region on the body was removed with an electric clipper over an area of 8 cm x 8 cm
- Area of exposure: 2.5 x 2.5 cm, covered with gauze
- Type of wrap if used: gauze, fixed with plaster (Leukoflex) covered with cellulose and fixed with an elastic bandage (Eloflex) (semi-occlusive)
REMOVAL OF TEST SUBSTANCE
- Washing: with water or olive oil
- Time after start of exposure: 4 hours
SCORING SYSTEM: according to the score of Draize - Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No signs of systemic toxicity were observed during the observation period
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In the experimental conditions described by OECD guideline 404 for evaluation of the acute dermal irritation / corrosivity of the substance Disperse Violet 93:1 is detemined to be not irritating to the skin.
- Executive summary:
About 24 hours before the start of the study the hair in the dorsal region of the body of 3 rabbits was removed with an electric clipper over an area of about 64 cm². Only animals with intact skin were used.
Each animal was treated with 0.5 g Disperse Violet 93:1 pasted with water. The substance was applied on the skin and covered with 2.5 x 2.5 cm² of medical gauze. The gauze was then covered with a semi-occlusive bandage.
The exposure period was 4 hours. After the exposure period all remnants of the test substance were carefully removed from the skin with water or olive oil.
No signs of skin irritation was observed at any observation point. hence, Disperse Violet 93:1 is not irritating to skin.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 18. Oct. to 25. Oct. 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- HC:NZW Albino Rabbits
Source: : Interfauna UK Ltd
Food: ssniff K 4
Supplier: sniff Spezialdiaten GmbH, Soest/Westfal
Water: Tap water
Food 100 to 120 g per animal per day; once per day in the morning
water ad libitum
Single housing
Weight: 2.3 to 3.4 kg
In-life date: 18. Oct to 25. Oct. 1988 - Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 100 µL (approx. 10 mg)
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- The eyes were examined 1, 24, 48, 72 hours and 7 days after application of the test substance.
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: yes with isotonic saline
- Time after start of exposure: 24 hours
TOOL USED TO ASSESS SCORE: fluorescein; at 24 hours the eyes were also examined for corneal lesion under UV light and white light after instillation of one drop of 1% fluorescein solution. Cornea, Iris, aqueous humor by means of a hand-slit lamp
SCORING SYSTEM: according to OECD guideline 405 - Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Slight reddening and lachrimation (both Score 1) was observed in all animals at the 1 hour observation point. No adverse effects were seen thereafter.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Testing of Disperse Violet 93:1 for primary eye irritation in the rabbit showed, that the substance is not irritating to eyes.
- Executive summary:
100 µL (10 mg) of Disperse Violet 93:1was applied once to the conjunctival sac of the left eye of three rabbits. The untreated eyes served in each case as a control.
24 hours after application the treated eyes were washed out thoroughly with isotonic saline.
The eyes were examined 1, 24, 48 and 72 hours and 7 days after application of the test substance.
At 24 hours the eyes were also examined for corneal lesions under UV light after instillation of one drop of 1 % fluorescein solution. Lesions in cornea. iris or conjunctivae were graded numerically. All other changes or toxic effects were recorded.
Slight reddening and lachrimation (both Score 1) was observed in all animals at the 1 hour observation point. No adverse effects were seen thereafter.
Hence, Disperse Violet 93:1 is not irritating to eyes.
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- NZW Albino Rabbits
Source: Lippische Versuchstierzucht, Hagemann GmbH & Co. KG, Extertal
Food: mümmel Z
Supplier: sniff Spezialdiaten GmbH, Soest/Westfal
Water: Tap water
Food 100 to 120 g per animal per day; once per day in the morning
water ad libitum
Single housing
Weight: mean 2.2 kg
Acclimation: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature: 16-18°C
- Humidity: approx. 40 %
- Lighting time: 12 hours daily - Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 100 µL (ca. 10 mg)
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- The eyes were examined 1, 24, 48, 72 hours and 8 days after application of the test substance.
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no removal of test substance
- Time after start of exposure: NA
SCORING SYSTEM: Draize
TOOL USED TO ASSESS SCORE: ophthalmoscope
fluorescein: at 24 hours the eyes were also examined for corneal lesion under UV light after instillation of one drop of fluorescein solution. - Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Remarks on result:
- no indication of irritation
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Testing of Disperse Violet 93:1 for primary eye irritation in the rabbit showed, that the substance is not irritating to eyes.
- Executive summary:
100 µL of Disperse Violet 93:1was applied once to the conjunctival sac of the left eye of three rabbits. The untreated eyes served in each case as a control.
The treated eyes were examined 1, 24, 48 and 72 hours and 8 days after application of the test substance.
At 24 hours the eyes were also examined for corneal lesions under UV light after instillation of one drop of a fluorescein-solution.
According to the study performed, Disperse Violet 93:1 is not irritating to eyes.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
For skin irritation testing, each animal was treated with 0.5 g Disperse Violet 93:1 pasted with water.
Examinations of the skin took place after 60 minutes as well as 24, 48 and 72 hours and 7/8 days after removal of the patches.
Erythema, eschar formation and oedema were evaluated numerically according to the score of DRAIZE. All other changes of the skin were recorded.
No signs of irritation occurred during the whole study.
Testing of Disperse Violet 93:1 for primary dermal irritation in the rabbit showed, that the substance is not irritating to skin.
100 µL (ca. 10 mg) Disperse Violet 93:1was applied once to the conjunctival sac of the left eye of three rabbits. The untreated eyes served in each case as a control.
The eyes were examined 1, 24, 48 and 72 hours and 7/8 days after application of the test substance.
At 24 hours the eyes were also examined for corneal lesions under UV light after instillation of one drop of a fluorescein solution. Lesions in cornea. iris or conjunctivae were graded numerically. All other changes or toxic effects were recorded.
Based on the individual scores after 24, 48 and 72 hours, no signs of irritation were noted
Testing of Disperse Violet 93:1 for primary eye irritation in the rabbit showed, that the substance is not irritating to the eye.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.