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Diss Factsheets
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EC number: 255-527-0 | CAS number: 41741-86-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
There were no studies available in which the toxicokinetic properties of the test substance were investigated. The test substance (molecular weight of 715.6 g/mol) is a brown solid powder with a log Pow of 0.81 and a water solubility of 240 mg/L at 23°C and at pH 5. The vapor pressure was not determined since the substances decomposes without melting.
In an acute toxicity study in rats no mortality and no systemic findings were observed after oral administration of test substance at a dose level of 5000 mg/kg body weight. Therefore, no conclusion can be drawn regarding systemic distribution. Generally, the smaller the molecule, the more easily it may be taken up. Molecular weights below 500 g/mol are favorable for absorption; molecular weights above 1000 g/mol do not favor absorption (ECHA GD 7c, 2008). The test article is characterized by a high molecular weight which, however, is still at a range where absorption in the gastrointestinal tract cannot be excluded. The water solubility of the test article is low, thus not favoring the substance to be readily dissolved in gastrointestinal fluids. Therefore, the potential for absorption through the gastrointestinal tract is considered to be low but cannot be ruled out. In a subacute repeated dose toxicity study (OECD 422), no toxicological relevant effects were reported up to the highest dose tested (1000 mg/kg body weight). No indications of systemic availability could be obtained in this study. The bioaccumulation potential is therefore regarded as low. Based on the sensitization studies which showed positive findings in guinea pigs, dermal penetration does occur. No data from acute or repeated dose toxicity studies by the inhalation route are available which could provide information about the systemic distribution of the test substance after inhalation. No data on the vapor pressure are available. The excretion pathway is largely dependent on molecular size, polarity and water solubility. The parent compound is expected to be excreted mainly via feces. Potential metabolites are either excreted via feces or urine, depending on their molecular size and water solubility after phase II metabolism.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.