Registration Dossier
Registration Dossier
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EC number: 253-021-4 | CAS number: 36411-52-6
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 31 October 2017- 01 March 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- GLP compliance:
- yes (incl. QA statement)
- Media:
- soil/sewage sludge
Test material
- Reference substance name:
- 2-hydroxy-N-1H-1,2,4-triazol-3-ylbenzamide
- EC Number:
- 253-021-4
- EC Name:
- 2-hydroxy-N-1H-1,2,4-triazol-3-ylbenzamide
- Cas Number:
- 36411-52-6
- Molecular formula:
- C9H8N4O2
- IUPAC Name:
- 2-hydroxy-N-1H-1,2,4-triazol-3-ylbenzamide
- Test material form:
- solid: particulate/powder
- Details on test material:
- Batch:102Z5
Purity: 99.9%
white powder
Constituent 1
- Radiolabelling:
- no
Study design
- Test temperature:
- 30 °C
HPLC method
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus:Agilent Technologies 1100, incorporating workstation and autosampler
- Type: variable wavelength (VW)
- Type, material and dimension of analytical (guard) column: Xselect HSS cyano 5μ (150 x 4.6 mm id)
MOBILE PHASES
- Type: methanol:water (55:45 v/v)
- pH: 7.0
- Solutes for dissolving test and reference substances: Test item (0.0102 g) was diluted to 200 mL with methanol:3% acetic acid (60:40 v/v) to give a concentration of 51 mg/L. Solutions of reference standards were prepared in methanol.
DETERMINATION OF DEAD TIME
- Method: by means of homologous series / by inert substances which are not retained by the column: The dead time was determined by measuring the retention time of formamide (purity 99.6%) of a 602 mg/L solution in methanol:water (55:45 v/v).
REFERENCE SUBSTANCES
- Identity: Acetanilide, Atrazine, Triadimenol, Linuron, Naphthalene, Endosulfan-diol, Fenthion, a-Endosulfan, Phenanthrene, Diclofop-methyl, DDT
Results and discussion
Adsorption coefficientopen allclose all
- Key result
- Sample No.:
- #1
- Type:
- log Koc
- Value:
- ca. 1.04 dimensionless
- Temp.:
- 30 °C
- Matrix:
- Xselect HSS cyano 5μ (150 x 4.6 mm id) column
- Key result
- Sample No.:
- #2
- Type:
- log Koc
- Value:
- ca. 1.04 dimensionless
- Temp.:
- 25 °C
- Matrix:
- Xselect HSS cyano 5μ (150 x 4.6 mm id) column
Results: HPLC method
- Details on results (HPLC method):
- - Retention times of reference substances used for calibration: Table 1
- Details of fitted regression line (log k' vs. log Koc): See attached illustration
Any other information on results incl. tables
Table 1
Standard |
Retention Time (min) |
Mean Retention Time (min) |
Capacity Factor (k') |
Log10k' |
Log10Koc |
|
Injection 1 |
Injection 2 |
|||||
Formamide (Dead Time) |
1.880 |
1.885 |
1.883 |
- |
- |
- |
Acetanilide |
2.629 |
2.634 |
2.631 |
0.397 |
-0.401 |
1.25 |
Atrazine |
3.683 |
3.669 |
3.676 |
0.952 |
-2.12 X 10-2 |
1.81 |
Triadimenol |
5.389 |
5.403 |
5.396 |
1.866 |
0.271 |
2.40 |
Linuron |
5.549 |
5.564 |
5.556 |
1.951 |
0.290 |
2.59 |
Naphthalene |
4.752 |
4.747 |
4.750 |
1.523 |
0.183 |
2.75 |
Endosulfan-diol |
6.992 |
6.978 |
6.985 |
2.710 |
0.433 |
3.02 |
Fenthion |
8.372 |
8.387 |
8.379 |
3.45 |
0.538 |
3.31 |
a-Endosulfan |
12.046 |
12.031 |
12.038 |
5.394 |
0.732 |
4.09 |
Diclofop-methyl |
12.998 |
12.998 |
12.998 |
5.903 |
0.771 |
5.20 |
Phenanthrene |
9.111 |
9.096 |
9.103 |
3.835 |
0.584 |
4.09 |
DDT |
26.147 |
26.176 |
26.161 |
12.894 |
1.11 |
5.63 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The adsorption coefficient of the test item has been determined to be 11.0, log10 Koc of 1.04. The result classified the test item as having very high mobility.
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