2-[7-(diethylamino)-2-oxo-2H-1-benzopyran-3-yl]quinazolin-4(1H)-one

Melting point / freezing point

Administrative data

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

August 24, 2017 - August 29, 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2017

Report date:

2017

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Deviations:

no

GLP compliance:

no

Type of method:

differential scanning calorimetry

Test material

Test material information

Constituent 1

Reference substance name:

3-(5-chlorobenzoxazol-2-yl)-7-(diethylamino)-2-benzopyrone

EC Number:

252-722-2

EC Name:

3-(5-chlorobenzoxazol-2-yl)-7-(diethylamino)-2-benzopyrone

Cas Number:

35773-43-4

Molecular formula:

C20H17ClN2O3

IUPAC Name:

3-(5-chloro-1,3-benzoxazol-2-yl)-7-(diethylamino)-2H-chromen-2-one

Test material form:

solid

Results and discussion

Melting / freezing point

Key result

Melting / freezing pt.:

203.2 °C

Decomposition:

yes

Any other information on results incl. tables

Melting point / melting range: DSC measurement

Three DSC measurements with a heating rate of 10 K/min showed an endothermal effect (melting) in the temperature range of 190 – 215 °C. The onset temperature (seeTable1) was derived from the intersection of the tangent line with the highest slope of the endothermal peak with the baseline.

The first and the second DSC measurements showed an additional exothermal effect in the temperature range of 365 – 495 °C.

The results of the DSC measurements are summarized inTable 1.

Table1: Melting point (DSC measurements)

Ident No.	Test item / mg	Starting temperature / °C	Final test temperature / °C	Temperature range (endo-thermal) / °C	Onset (melting) / °C	Crucible	Observations after the measurement
36543	9.36	25	500	195 – 210	202.6 °C	Aluminium with a hole	-
36545	8.89	25	500	190 – 215	203.6 °C	Aluminium with a hole	-
36557	8.30	25	260	195 – 215	203.5 °C	Aluminium with a hole	Test item was a solidified yellow melt

The test item had a melting point of 203.2°C (mean onset temperature).

Boiling point / boiling range:DSC measurement

No endothermal effects were observed after the melting and before the exothermal effect. The DSC measurements showed therefore no boiling after the melting effect and before the decomposition started. It decomposed before boiling could occur. The

test item had no boiling point under atmospheric conditions.

Applicant's summary and conclusion

Executive summary:

The test item Disperse Yellow 184.1 had a melting point of 203.2°C (mean onset temperature).

The test item Disperse Yellow 184.1 had no boiling point under atmospheric conditions. It decomposed before boiling could occur.