Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 241-460-4 | CAS number: 17439-11-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- adopted 2004-04-13
- Deviations:
- no
- GLP compliance:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- Samples of all test solutions were taken for chemical analysis. Samples were taken from all respective test solutions at test start (fresh) and after 48 h exposure (aged). The test solutions were analysed for fluoride and titanium. Samples of fresh and aged test media of all treatments and the control were analysed using an ISE probe for fluoride and ICP-MS for titanium.
Results can be found in the field "Any other information on results incl. tables" below. - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
A solution was prepared by dissolving 5000 mg of the test item in 5000 mL of copper-reduced dilution water and stirring for 2 h at 300 rpm. Aliquots of this solution were diluted with copper-reduced dilution water to create the test concentrations of 1.0, 10.0, 100, 300, and 1000 mg/L. The control test media was copper-reduced dilution water only. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Age at study initiation: less than 24h
- Feeding during test: the daphnids were not fed during the test - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- none
- Hardness:
- 1.1 mmol/L
- Test temperature:
- 20 ± 0.1°C
- pH:
- The solution pH decreased with increasing test concentration from 8.51 to 4.08, but remained stable in individual test vessels during the test.
- Dissolved oxygen:
- The oxygen saturation was >3 mg/L in all solutions with the mean value 8.3 mg/L.
- Salinity:
- no data
- Nominal and measured concentrations:
- Test concentrations (nominal loadings): 1, 10, 100, 300, and 1000 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 60 mL glass beakers; Approximately 50 mL of test solution was added to the test vessels followed by the daphnids.
- Aeration: test vessel were not aerated
- Renewal rate of test solution (frequency/flow rate): the test solutions were not renewed.
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water:copper-reduced dilution water
OTHER TEST CONDITIONS
- Photoperiod: light/dark cycle of 16/8 hours
- Light intensity: 523-546lux
- Oxygen and pH: the pH and oxygen saturation of the test solutions were measured from pooled vessels at test end.
EFFECT PARAMETERS MEASURED:
After 24 h and 48 h exposure to the test item, the number of immobile daphnids in each beaker was counted. The daphnids were considered to be immobile if they were not able to swim within 15 seconds of gentle agitation of the test vessels. Any abnormalities in appearance and behaviour were also recorded. - Reference substance (positive control):
- no
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 48.2 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95%CL: 27.6-74.4
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Mortality of 50, 100, and 100% compared to the control was observed at 100, 300, and 1000 mg/L after 24 h.
- After 48 h, 75% mortality was recorded at 100 mg/L.
- There was no mortality in the control.
- No signs of disease or stress were observed.
- All surviving specimens gave the impression of healthy condition. - Results with reference substance (positive control):
- not examined
- Reported statistics and error estimates:
- The endpoint of the test was mortality, and the respective LCx, NOEC, and LOEC values were determined. The NOEC and LOEC were determined based on the observation of mortality. Probit analysis was performed to plot dose-response curves and to estimate the EC50, assuming log-normal distribution of the values. The computer software ToxRat® Professional was used for statistical evaluations.
- Validity criteria fulfilled:
- yes
- Conclusions:
- Estimated EC50 (calculated): 48.2 mg/L (based on nominal concentration)
NOEC: 10.0 mg/L (nominal concentrations)
Mortality of 50, 100, and 100% compared to the control was observed at 100, 300, and 1000 mg/L after 24 h. After 48 h, 75% mortality was recorded at 100 mg/L. There was no mortality in the control. No signs of disease or stress were observed. All surviving specimens gave the impression of healthy condition. - Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- 1. HYPOTHESIS FOR THE ANALOGUE APPROACH
Dihydrogen hexafluorotitanate is an inorganic substance which will rapidly dissociate into fluoride, potassium and titanium ions upon dissolution in the environment or the human body, and so, similar toxicological properties can be assumed. However, titanium ions do not remain in solution, only fluoride ions do. The approach follows scenario 1 of the RAAF (ECHA 2017). For details, see attached Read-Across statement in IUCLID chapter 13.2.
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
Source
Dipotassium hexafluorotitanate (CAS 16919-27-0)
Target
Dihydrogen hexafluorotitanate (CAS 17439-11-1)
3. ANALOGUE APPROACH JUSTIFICATION
Since dihydrogen hexafluorotitanate rapidly dissociates into fluoride, protons and titanium ions upon dissolution in aqueous solutions, such as the environment or human body, and only fluoride but not titanium ions will remain in solution, it can be assumed that toxicity (if any) will be driven by the fluoride anion. The non-common dissociation products, potassium, sodium, or just hydrogen ions, are considered not to influence the (eco)toxicological profile of Ti2-F6 to a significant degree. These ions are present in the environment and in the human body in considerable amounts. Potassium and sodium levels influence multiple physiological processes. The body has mechanisms to protect from the intake of harmful concentrations of those.
This read-across is based on the hypothesis that source and target substances have similar (eco)toxicological properties, because they dissociate to common anion. The target substance dihydrogen hexafluorotitanate and the source substance dipotassium hexafluorotitanate form hexafluorotitanate species in aqueous solution. Hexafluorotitanate is considered to be (eco)toxicologically relevant, whereas potassium ions are essential elements and practically non-toxic.
For additional information, please refer to the attached read-across statement in IUCLID chapter 13.2.
4. DATA MATRIX
Please refer to the attached read-across statement in IUCLID chapter 13.2. - Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 53.9 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: converted to the target substance
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 11.2 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: converted to the target substance
- Duration:
- 48 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 111.8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: converted to the target substance
- Details on results:
- - Mortality of 50, 100, and 100% compared to the control was observed at 100, 300, and 1000 mg/L after 24 h.
- After 48 h, 75% mortality was recorded at 100 mg/L.
- There was no mortality in the control.
- No signs of disease or stress were observed.
- All surviving specimens gave the impression of healthy condition. - Results with reference substance (positive control):
- not examined
- Reported statistics and error estimates:
- The endpoint of the test was mortality, and the respective LCx, NOEC, and LOEC values were determined. The NOEC and LOEC were determined based on the observation of mortality. Probit analysis was performed to plot dose-response curves and to estimate the EC50, assuming log-normal distribution of the values. The computer software ToxRat® Professional was used for statistical evaluations.
- Validity criteria fulfilled:
- yes
- Conclusions:
- Estimated EC50 (calculated): 48.2 mg/L (based on nominal concentration)
NOEC: 10.0 mg/L (nominal concentrations)
Mortality of 50, 100, and 100% compared to the control was observed at 100, 300, and 1000 mg/L after 24 h. After 48 h, 75% mortality was recorded at 100 mg/L. There was no mortality in the control. No signs of disease or stress were observed. All surviving specimens gave the impression of healthy condition. The EC50 converted to the target substance corresponds to 53.9 mg/L.
Referenceopen allclose all
Description of key information
The acute toxicity of the structural analogue dipotassium hexafluorotitanate to Daphnia magna was tested according to OECD 203; an EC50 of 53.9 mg/L was recalculated for dihydrogen hexafluorotitanate.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- 53.9 mg/L
Additional information
Dihydrogen hexafluorotitanate
The acute toxicity of the structural analogue dipotassium hexafluorotitanate to Daphnia magna was tested according to OECD 202. An EC50 of 53.9 mg/L was recalculated for dihydrogen hexafluorotitanate (conversion from K2TiF6 value and corrected to max. purity). Information on the read-across approach has been attached in IUCLID section 13.2.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)