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EC number: 240-914-9 | CAS number: 16881-77-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation: not irritating (OECD TG 404, RA from CAS 2031-62-1)
Eye irritation: not irritating (OECD TG 405, RA from CAS 2031-62-1)
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to the attached read-across justification.
- Reason / purpose for cross-reference:
- read-across source
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Interpretation of results:
- other: CLP/EU GHS criteria are not met, no classification required according to Regulations (EC) No 1272/2008
- Conclusions:
- No irritation potential was observed with the source substance, thus no irriation potential is estimated for the target substance. As explained in the analogue justification, it is considered that the target and the source substances are unlikely to lead to differences in skin irritation potential.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to the attached read-across justification.
- Reason / purpose for cross-reference:
- read-across source
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- over all three animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: reversibility: not applicable
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- over all three animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: reversibility: not applicable
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- out of animals #1 and #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- other: reversibility: not applicable
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- over all three animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: reversibility: not applicable
- Irritant / corrosive response data:
- Animal No. 1 and 3 showed redness grade 1 of the conjunctivae 1 hour post instillation. 24 hours post instillation until the end of the observation period no signs of irritation were recorded.
Animal No. 2 showed redness grade 1 of the conjunctivae 1 hour, as well as 24 hours post instillation. 48 hours, as well as 72 hours post instillation no signs of irritation were recorded. - Other effects:
- Throughout the observation period not weight loss was observed for the test animals.
- Interpretation of results:
- other: CLP/EU GHS criteria are not met, no classification required according to Regulations (EC) No 1272/2008
- Conclusions:
- In conclusion, it was shown that the source substance is not irritating to the eyes. This is also estimated for the target substance. As explained in the analogue justification, it is considered that the target and the source substances are unlikely to lead to differences in eye irritation potential.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No measured irritation data are available for the registered substance dimethoxy(methyl)silane (CAS 16881-77-9), however, data are available for the structural analogue diethoxy(methyl)silane (CAS 2031-62-1). Both substances hydrolyse in contact with water to produce the common silanol hydrolysis products, methylsilanediol and methylsilanetriol. Therefore, it is considered that read-across between the substances is appropriate.
In the key skin irritation study performed according to OECD TG 404 and in compliance with GLP (BSL, 2007), three female New Zealand White rabbits were exposed to 0.5 mL of the neat test material (CAS 2031-62-1) for 4 hours applied onto the clipped skin via semi-occlusive dressing. Skin reactions were evaluated 1, 24, 48 and 72 hours post-application. Neither erythema nor edema formation were observed during the study period. There were no remarkable body weight changes during the contact and observation period.
Based on the above study result on the source substance diethoxy(methyl)silane (CAS 2031-62-1) and according to EU classification criteria, dimethoxy(methyl)silane (CAS 16881-77-9) is considered to be not irritating to the skin.
In the key eye irritation study performed according to OECD TG 405 and in compliance with GLP (BSL, 2007), 0.1 mL of diethoxy(methyl)silane (CAS 2031-62-1) was instilled in the eye of three female New Zealand White rabbits. The eyes were examined and the changes were graded according to the Draize scoring system 1, 24, 48 and 72 hours post-application. All animals showed redness (grade 1) of the conjunctivae 1 hour post-application which was fully reversible within 48 hours post-application. No further signs of irritation and no remarkable body weight changes were noted during the study period.
Based on the above study result on the source substance diethoxy(methyl)silane (CAS 2031-62-1) and according to EU classification criteria, dimethoxy(methyl)silane (CAS 16881-77-9) is considered to be not irritating to the eyes.
Justification for classification or non-classification
The available data on skin and eye irritation for the structural analogue substance do not meet the criteria for classification according to Regulation (EC) No. 1272/2008 and are therefore conclusive but not sufficient for classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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