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Diss Factsheets
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EC number: 233-796-5 | CAS number: 10361-80-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute toxicity - oral:
A K2 acute oral toxicity test was performed in female Sprague-Dawley rats according to a guideline similar to OECD Guideline 401 (Bruce DW, 1963). This study was selected as key study.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Sufficiently documented acute oral toxicity study in female rats performed according to a method equivalent to OECD Guideline 401.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data
- Age at study initiation: adult
- Weight at study initiation: 190 g to 250 g
- Fasting period before study: no data
- Housing: Animals were housed in air-conditioned quarters
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: no data - Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
50% aqueous solution - Doses:
- unknown
- No. of animals per sex per dose:
- 5 or 10 animals per group
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 30 days
- Statistics:
- On the basis of the mortality that occurred during the 30-day observation period, the LD50 values with 95% confidence limits were calculated by the method of Litchfield and Wilcoxon (1949).
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 3 500 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 3 017 - 4 060
- Mortality:
- The animals were observed for 30 days although no deaths occurred later than 4 days after administration of the nitrate salts by the oral route.
- Clinical signs:
- other: Within 1 to 2 hours after oral administration of the rare earth nitrates most of the rats were depressed, and animals that received lethal doses showed little activity during the survival period.
- Gross pathology:
- Throughout the observation period no gross pathologic changes were noted.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute oral LD50 of praseodymium nitrate in female rats was determined to be 3500 mg/kg. The test substance is considered not classified according to the criteria of the CLP Regulation.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 500 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Acute toxicity: oral
Bruce DW (1963) investigated the acute oral toxicity via gavage of a single oral dose of praseodymium nitrate in 5 to 10 female Sprague-Dawley rats. The animals were observed for 30 days although no deaths occurred later than 4 days after administration. Within 1 to 2 hours after oral administration of the rare earth nitrates most of the rats were depressed, and animals that received lethal doses showed little activity during the survival period. Throughout the observation period no gross pathologic changes were noted. The acute oral LD50 of praseodymium nitrate in female rats was determined to be 3500 mg/kg.
No data were available for the inhalation and dermal route.
Justification for classification or non-classification
Based on the results of the acute oral toxicity study and according to the criteria of the CLP Regulation, praseodymium trinitrate should not be classified as an acute oral toxicant.
No data were available to decide on the classification for the inhalation and dermal route.
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