Registration Dossier
Registration Dossier
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EC number: 229-551-7 | CAS number: 6606-59-3
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other: QSAR Toolbox
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Guideline:
- other: REACH guidance on QSARs R.6, May/July 2008
- Principles of method if other than guideline:
- General model for narcosis (polar and non-polar)
Test material
- Reference substance name:
- 1,6-hexanediyl bismethacrylate
- EC Number:
- 229-551-7
- EC Name:
- 1,6-hexanediyl bismethacrylate
- Cas Number:
- 6606-59-3
- Molecular formula:
- C14H22O4
- IUPAC Name:
- 6-[(2-methylprop-2-enoyl)oxy]hexyl 2-methylprop-2-enoate
- Test material form:
- other: liquid
Constituent 1
Results and discussion
Effect concentrations
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Remarks:
- Daphnia magna
- Effect conc.:
- 11.9 mg/L
Any other information on results incl. tables
EC50 Daphnia magna (48h) of 1,6 -hexandiol dimethacrylate (11.2 mg/L) is predicted from category members (Methacrylates with an unspefic mechanism) using trend analysis based on 12 values within the range 2.57 - 380 mg/L from 12 category members. Category members are single chemicals and are selected based on the profile of the target chemical. Only chemicals having
experimental data are listed in the category. The target chemical FALLS within applicability domain of the prediction. The data used for calculating the current prediction is taken from 12 experimental values selected from the following database(s): 1. ECHA CHEM
Applicant's summary and conclusion
- Conclusions:
- EC50 Daphnia magna (48h): 11.2 mg/l predected based on QSAR
- Executive summary:
EC50 Daphnia magna (48h) of 1,6 -hexandiol dimethacrylate (11.2 mg/L) is predicted from category members (Methacrylates with an unspefic mechanism) using trend analysis based on 12 values within the range 2.57 - 380 mg/L from 12 category members. Category members are single chemicals and are selected based on the profile of the target chemical. Only chemicals having
experimental data are listed in the category. The target chemical FALLS within applicability domain of the prediction. The data used for calculating the current prediction is taken from 12 experimental values selected from the following database(s): ECHA CHEM
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