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EC number: 229-542-8 | CAS number: 6600-31-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
A valid acute oral and dermal toxicity study and 2 acute inhalation toxicity studies are available. In the acute inhalation toxicity studies no exact LC50 values were determined.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable and sufficient documented
- Principles of method if other than guideline:
- Ten male rats received a single dose (2500 or 5000 mg/kg bw) per gavage. The animals were observed for mortality, body weight gain and clinical signs through day 14.
- GLP compliance:
- no
- Test type:
- standard acute method
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Route of administration:
- oral: gavage
- Vehicle:
- other: Lutrol
- Doses:
- 2500 or 5000 mg/kg bw
- No. of animals per sex per dose:
- 10 male rats per dose
- Control animals:
- not specified
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- relatively harmless
- Remarks:
- Migrated information
- Executive summary:
Ten male rats received a single dose (2500 or 5000 mg/kg bw) per gavage. The animals were observed for mortality, body weight gain and clinical signs through day 14.
None of the animals which received a dose of 2500 mg/kg bw died and no clinicla signs were observed. One animal our of 10 died which received a dose of 5000 mg/kg bw. The animal died after 2 days. No clinicla signs were observed on the animals which survived.
Signs of intoxication were sedation and a decrease of the general condition.
The LD50 is > 5000 mg(kg bw (male rats)
Reference
None of the animals which received a dose of 2500 mg/kg bw died and no clinicla signs were observed. One animal our of 10 died which received a dose of 5000 mg/kg bw. The animal died after 2 days. No clinicla signs were observed on the animals which survived.
Signs of intoxication were sedation and a decrease of the general condition.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- The materials/methods and results are described sufficient for evaluation
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No LC50 determined - highest applied dose caused no deaths and no clinical signs
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- The test substance was heated in a 400 liter chamber to 150 °C. Female rats and female mice as well as male hamsters and male rabbits were exposed to the vapours of the test substance for 4 hours. During a post-observation period of 14 days the animals were observed for mortality and clinical signs.
- GLP compliance:
- no
- Test type:
- standard acute method
- Species:
- other: rat, mouse, hamster, rabbit
- Strain:
- other: Wistar rats; NMRI mice; New Zealand white rabbits
- Sex:
- male/female
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- gravimetric analysis of vaporised product
- Duration of exposure:
- 4 h
- Concentrations:
- 6742 mg/m³: mice male
6742 mg/m³: rat, male
8000 mg/m³: hamster
8000 mg/m³: rabbbit - No. of animals per sex per dose:
- 20 mice, 10 rats, 5 hamsters, and 2 rabbits
- Control animals:
- no
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 6.74 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: rats
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 6.74 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: mice
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 8 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: hamsters
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 8 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: rabbits
- Executive summary:
The test substance was heated in a 400 liter chamber to 150 °C. Female rats and female mice as well as male hamsters and male rabbits were exposed to the vappours of the test substance for 4 hours. During a post-observation period of 14 days the animals were observed for mortality and clinical signs.
None of the rats and mice died (mortality: 0/10 female rats and 0/20 female mice). A concentration of 6742 mg/m³ was tolerated by the animals without symptoms. None of the hamsters and rabbits died (mortality: 0/5 male + female hamsters and 0/2 male + female rabbits). A concentration of 8000 mg/m³ was tolerated by the animals without symptoms.
Therefore the LC50 is > 6742 mg/m³ for male rats and mice. The LC50 for male and female hamsters and rabbits is > 8000 mg/m³.
Reference
The test substance was vaporised at 150°C
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- discriminating conc.
- Value:
- 6 742 mg/m³ air
- Quality of whole database:
- The materials/methods and results are described sufficient for evaluation
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable and sufficient documented
- Principles of method if other than guideline:
- Five male and five female rats received a single dose (1000 or 5000 mg/kg bw) of KAC 4196 as emulsion in cremophor for 24 hours. The animals were observed for mortality, body weight gain and clinical signs through day 7.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Type of coverage:
- not specified
- Vehicle:
- other: cremophor
- Duration of exposure:
- 24 hours
- Doses:
- 1000 or 5000 mg/kg bw
- No. of animals per sex per dose:
- 5 male and 5 female rats/dose
- Control animals:
- not specified
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Executive summary:
Five male and five female rats received a single dose (1000 or 5000 mg/kg bw) of KAC 4196 as emulsion in cremophor for 24 hours. The animals were observed for mortality, body weight gain and clinical signs through day 7.
None of the animals died. The animals dosed with 1000 mg/kg bw were without findings. Animals which were treated with 5000 mg/kg bw revealed a temporary reduced general condition during an observation period of 7 days. The LD50 dermal is > 5000 mg/kg bw (m + f rats)
Reference
None of the animals died. The animals dosed with 1000 mg/kg bw were without findings. Animals which were treated with 5000 mg/kg bw revealed a temporary reduced general condition during an observation period of 7 days.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- The materials/methods and results are described sufficient for evaluation
Additional information
In the acute oral toxicity study 2 groups of 10 male Wister rats (average weight 160-180 g) received per gavage a single dose of 2500 or 5000 mg/kg bw Ozonschutzmittel KAC 4196. The animals were observed for mortality, weight and clinical signs through day 14. None of the animals died.
In the acute dermal toxicity study 2 groups of 5 maleWistar rats were applied 1000 or 5000 mg/kg bw of the undiluted test substance for 24 hours. The animals were exmained for mortality. None of the animals died.
Two studies are available for acute inhalation toxicity. In one study the test substace was applied as vapour in concentrations of 6742 mg/m³ to male rats and mice and 8000 mg/m³ to hamsters and rabbits. In the other one the test substance was applied as dust in concentrations of 283 or 1517 mg/m³ to male and female rats. In both studies the highest applied dose caused not deaths and no characteristic clinical signs.
Justification for selection of acute toxicity – oral endpoint
key study used
Justification for selection of acute toxicity – inhalation endpoint
2 studies are available. In one study the test substace was applied as vapour and in the other one as dust. In both studies the highest applied dose caused not deaths and no (characteristic) clinical signs. In the vapor study rats, mice, hamster and rabbits were exposed to the test substance.
Justification for selection of acute toxicity – dermal endpoint
key study used
Justification for classification or non-classification
Two reliable acute toxicity studies are available. In the acute oral and acute dermal toxicity study the LD50 is > 5000 mg/kg bw.
Therefore a classification is not justified.
In the acute inhalation study where the test substance was applied as dust, the LC50 is > 1517 mg/m³ and in the acute inhalation study where the test substance was applied as vapour, the LC50 is > 6742 mg/m³. Therefore the inhalation studies are not reliable for a classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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