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EC number: 227-133-9 | CAS number: 5675-51-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics, other
- Type of information:
- other: toxicokinetics assessment
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The assessment of the toxicokinetics of 'Dodecane-1,12-diol' is based on physico-chemical properties of the compound and on toxicological data. Experimental toxicokinetic studies were not performed.
- Principles of method if other than guideline:
- assessment on toxicokinetics
Reference
The remarks on the toxicokinetics are based on physico-chemical properties of the compound and on toxicological data (Tegethoff, 2020). Experimental toxicokinetic studies were not performed.
Description of key information
Key value for chemical safety assessment
Additional information
The following remarks on the toxicokinetics of 'Dodecane-1,12-diol’ are based on physico-chemical properties of the compound and on toxicological data. Experimental toxicokinetic studies were not performed.
The physico-chemical characteristics of the registered substance in sum do not favour oral and/or dermal absorption.
- White solid
- molecular mass of 202.33 g/mol
- Low vapour pressure (4.3 x 10-5 Pa at 20°C)
- low water solubility (18.7 mg/L at 20°C) and
- log Pow of 3.1 (OECD TG 117)
Oral absorption:
The studies with oral exposure do not point to oral/gastrointestinal absorption.
A single oral dose of 10,000 mg/kg bw was tolerated in rats without mortalities, effects on body weight development and gross pathological findings (OECD TG 401). In a combined 28-day repeated dose toxicity study with reproduction/developmental toxicity screening on rats with oral exposure for > 28 days (OECD 422) and doses up to the limit dose of 1000 mg/kg bw/day no test item-related changes were noted in any of the parameters investigated. The No Observed Adverse Effect Levels (NOAEL) for 1,12-Dodecanediol was established to be at least 1000 mg/kg/day.
The results of the OECD 422 study did not reveal any indication of an accumulation potential of the substance.
Dermal absorption:
The studies with dermal exposure do not point to dermal absorption.
In vivo skin and eye irritation studies following OECD 404 and 405 did not reveal any signs of local toxicity. Also in vitro the registered substance showed no cytotoxic effects to skin and mucosal membrane tissues. In a skin sensitization study on mice following OECD 429 (LLNA) with doses of up to 10% in acetone/olive oil (4:1) no indication for skin irritation and/or skin sensitization became obvious.
Results of in vitro mutagenicity tests in bacteria (OECD 471) and mammalian cells (OECD 476 and 487) with and without metabolic activation showed that ‘Dodecane-1,12-diol’ is not a mutagen. Thus, it is concluded that DNA-reactive metabolites are not generated in the course of a potential hepatic biotransformation.
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