Registration Dossier
Registration Dossier
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EC number: 214-968-9 | CAS number: 1229-55-6
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from peer reviwed journals
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Principles of method if other than guideline:
- To determine the octanol water partition coefficient of Solvent Red 1 by HPLC method
- GLP compliance:
- not specified
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- - Name of test material: 1-[(2-methoxyphenyl)diazenyl]-2-naphthol
- Common Name: Solvent Red 1
- Molecular formula: C17H14N2O2
- Molecular weight: 278.31 g/mol
- Smiles notation: c12c(\N=N\c3c(cccc3)OC)c(ccc1cccc2)O
- InChl : 1S/C17H14N2O2/c1-21-16-9-5-4-8-14(16)18-19-17-13-7-3-2-6-12(13)10-11-15(17)20/h2-11,20H,1H3/b19-18+
- Substance type: Organic
- Physical state: Solid - Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 7.5
- Remarks on result:
- other: no other details mentioned
- Conclusions:
- The experimental octanol water partition coefficient (log Pow) of Solvent Red 1 was determined to be 7.5
- Executive summary:
Capacity factors were determined for 20 disperse and solvent dyes by a high performance liquid chromatographic method using methanol/water and a C-18 reverse-phase column. Regression equations are given that establish relationships among capacity factors, water solubilities and octanol/water partition coefficients. The method used was similar to OECD GUIDELINES 117.
The liquid chromatographic system comprised a PerkinElmer Series 2000 pump, a Varian Vari-Chrom absorbance detector and an Alltech Econosil C-18 (10.urn)column (4,6 mm x 25 cm with guard column). The mobile phase, HPLC-grade methanol and deionized water (75/25 vol. %), was filtered for use at a flow rate of 1,3 ml/min, Detection was at the wavelength of maximum absorbance in the visible spectra.
The experimental octanol water partition coefficient (log Pow) of Solvent Red 1 was determined to be 7.5
Reference
Description of key information
Capacity factors were determined for 20 disperse and solvent dyes by a high performance liquid chromatographic method using methanol/water and a C-18 reverse-phase column. Regression equations are given that establish relationships among capacity factors, water solubilities and octanol/water partition coefficients. The method used was similar to OECD GUIDELINES 117.
The liquid chromatographic system comprised a PerkinElmer Series 2000 pump, a Varian Vari-Chrom absorbance detector and an Alltech Econosil C-18 (10.urn)column (4,6 mm x 25 cm with guard column). The mobile phase, HPLC-grade methanol and deionized water (75/25 vol. %), was filtered for use at a flow rate of 1,3 ml/min, Detection was at the wavelength of maximum absorbance in the visible spectra.
The experimental octanol water partition coefficient (log Pow) of Solvent Red 1 was determined to be 7.5
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 7.5
Additional information
Capacity factors were determined for 20 disperse and solvent dyes by a high performance liquid chromatographic method using methanol/water and a C-18 reverse-phase column. Regression equations are given that establish relationships among capacity factors, water solubilities and octanol/water partition coefficients. The method used was similar to OECD GUIDELINES 117.
The liquid chromatographic system comprised a PerkinElmer Series 2000 pump, a Varian Vari-Chrom absorbance detector and an Alltech Econosil C-18 (10.urn)column (4,6 mm x 25 cm with guard column). The mobile phase, HPLC-grade methanol and deionized water (75/25 vol. %), was filtered for use at a flow rate of 1,3 ml/min, Detection was at the wavelength of maximum absorbance in the visible spectra.
The experimental octanol water partition coefficient (log Pow) of Solvent Red 1 was determined to be 7.5
Data from various authoritative databases and peer reviewed articles also indicate that the experimental octanol water partition coefficient (log Pow) of Solvent Red 1 was 7.5
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