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EC number: 212-782-2 | CAS number: 868-77-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- part 1 "Daphnia sp., Acute Immobilisation Test
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Supplier: Wako Pure Chemical Ind.
Purity: 97.2 % - Analytical monitoring:
- yes
- Vehicle:
- no
- Details on test solutions:
- The material of a necessary amount is dissolved to the dilution water, and examination field liquid 10,000 mg/L is adjusted.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- -Test Organisms:
a) Age at Study Initiation: < 24 hours after hatching
b) Supplier/Source: Supplied from U.S. EPA Environmental Research Laboratory - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- not applicable
- Hardness:
- 55.6 mg/L
- Test temperature:
- 20.0 - 20.2 degree C
- pH:
- 6.7 - 7.2
- Dissolved oxygen:
- 8.4-8.7
- Salinity:
- Not Applicable
- Nominal and measured concentrations:
- 95.3, 171, 309, 556, 1000 mg/L- nominal
97.0, 177, 318, 568, 1010 mg/L-TWM measured - Details on test conditions:
- -Test Conditions:
a) Dilution Water Source: Dechlorination water
b) Dilution Water Chemistry: hardness= 55.6 mg/L CaCO3, pH= 7.7, chlorine concentration < 0.02 mg/L
c) Exposure Vessel Type: Petri dish (diameter = 8.5 cm, depth = 5.7 cm)
d) Nominal concentrations (as mg/L): 95.3, 171, 309, 556, 1000
e) Stock Solutions Preparation and Stability: The material of a necessary amount is dissolved to the dilution water, and examination field liquid 10,000 mg/L is adjusted.
f) Number of Replicates: 4
g) Individuals per Replicate: 5
h) Water Temerature Range: 20.0 - 20.2 degree C
i) Light Conditions: 16:8 hours; light darkness cycle - Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 171 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 380 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Reported statistics and error estimates:
- Binomial
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 48-hr EC50 was determined to be 380 mg/L in Daphnia magna.
- Executive summary:
A 48-hour toxicity study with 2-hydroxyethyl methacrylate to daphnids (Daphnia magna) was conducted acc. OECD 202 (part 1) under static conditions with 4 replicates of 5 daphnids per test concentration exposed to a nominal test concentrations of 0 (control), 95.3, 171, 309, 556, and 1000 mg/l. Water samples were measured for analytical verification of test concentrations at 0 and 48 hours. The resulting time-weighted mean measured concentrations were 0 (control), 97.0, 177, 318, 568, and 1010 mg/l. Immobility was observed for 15, 100, and 100% of the daphnids at the 318, 568, and 1010 mg/L test levels, respectively. No daphnid immobility was observed in the control or remaining test levels during the expsosure.
The 48-hour EC50 value was determined to be >380 mg/L.
Reference
Table 1: Measured concentration
Nominal Measured conc. (mg/L) (Percentage of nominal)
conc. --------------------------------------------------
(mg/L) 0 hour 48 hour Time-weighted mean
-------------------------------------------------------------
Control n.d. n.d. n.d.
-------------------------------------------------------------
95.3 99.5(104) 94.4(99.1) 97.0(102)
-------------------------------------------------------------
171 178(104) 175(102) 177(103)
-------------------------------------------------------------
309 319(103) 317(103) 318(103)
-------------------------------------------------------------
556 577(104) 558(100) 568(102)
-------------------------------------------------------------
1000 1010(101) 1010(101) 1010(101)
-------------------------------------------------------------
n.d.: < 5.00 mg/L
Table 2: Water chemistry in test
Nominal Measured value
conc. --------------------------------------------------
(mg/L) DO (mg/L) pH
--------------------------------------------------
0 hour 48 hour 0 hour 48 hour
-------------------------------------------------------------
Control 8.7 8.4 8.0 7.6
-------------------------------------------------------------
95.3 8.7 8.4 7.2 7.2
-------------------------------------------------------------
171 8.6 8.4 6.9 7.1
-------------------------------------------------------------
309 8.6 8.4 6.8 7.1
-------------------------------------------------------------
556 8.6 8.4 6.7 7.1 -------------------------------------------------------------
1000 8.6 8.5 6.7 7.0
-------------------------------------------------------------
Table 3: Number immobility as compared to the number exposed
Nominal Cumulative number of immobilized
Daphnia (Percentage immobility)
conc. --------------------------------------------------
(mg/L) 24 hour 48 hour
-------------------------------------------------------------
Control 0(0) 0(0)
-------------------------------------------------------------
95.3 0(0) 0(0)
-------------------------------------------------------------
171 0(0) 0(0)
-------------------------------------------------------------
309 0(0) 3(15)
-------------------------------------------------------------
556 8(40) 20(100)
-------------------------------------------------------------
1000 20(100) 20(100)
-------------------------------------------------------------
Description of key information
A short-term toxicity test with Daphnia magna exposed to 2-hydroxyethyl methacrylate under static conditions, and following standard test guidelines (OECD 202, part 1), resulted in 48-hour EC50 value of 380 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Remarks:
- 48 h
- Effect concentration:
- 380 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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