Registration Dossier
Registration Dossier
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EC number: 212-742-4 | CAS number: 865-49-6
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- GLP compliance:
- no
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- (2H)chloroform
- EC Number:
- 212-742-4
- EC Name:
- (2H)chloroform
- Cas Number:
- 865-49-6
- Molecular formula:
- CCl3D
- IUPAC Name:
- chloroform
- Test material form:
- liquid
Constituent 1
Study design
- Analytical method:
- gas chromatography
Results and discussion
Partition coefficientopen allclose all
- Key result
- Type:
- log Pow
- Partition coefficient:
- 1.5
- Temp.:
- 20 °C
- Remarks on result:
- other: calculated value (EPI suite)
- Remarks:
- due to high volatility of the substance, the calculated value (EPI suite) of log Pow in the study report is considered more reliable in terms of further assessment than the measured results.
- Type:
- log Pow
- Partition coefficient:
- > 1.6
- Temp.:
- 23 °C
- pH:
- 9
- Remarks on result:
- not determinable
- Remarks:
- due to high volatility of the substance, all measurements of D-Chloroform in the aqueous phase were below the detection limit of the analytical system.
- Details on results:
- Partition coefficients of the shake flask method at pH 9:
Experiment No.:
1A) Pow >38.0, log Pow >1.58
1B) Pow >39.9, log Pow >1.60
2A) Pow >20.5, log Pow >1.31
2B) Pow >20.4, log Pow >1.31
3A) Pow >11.2, log Pow >1.05
3B) Pow >10.6, log Pow >1.02
The partition coefficient showed a tendency within the measurement series. This tendency was caused because the concentration of the test item in water was in all tests below the detection limit. Following a conservative approach the highest value was given as result.This value is also in good accordance with the value obtained via EpiSuite (log Pow = 1.5).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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