Registration Dossier
Registration Dossier
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EC number: 211-581-7 | CAS number: 670-96-2
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 4 - 24 October 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- 2004
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- 2-phenylimidazole
- EC Number:
- 211-581-7
- EC Name:
- 2-phenylimidazole
- Cas Number:
- 670-96-2
- Molecular formula:
- C9H8N2
- IUPAC Name:
- 2-phenyl-1H-imidazole
- Test material form:
- solid: flakes
Constituent 1
Results and discussion
Partition coefficient
- Key result
- Type:
- log Pow
- Partition coefficient:
- 1.29
- Temp.:
- 25 °C
- pH:
- 7.5
Any other information on results incl. tables
RESULTS
PARTITION COEFFICIENT (n-OCTANOL/WATER) ACCORDING TO OECD 117
The results are reported below:
Calibration line of the reference standards
slope 1,4577
intercept 1,0768
correlation 0,9903
R2 0,9808
The calibration reference standards, consist of 6 reference substances of known log Pow: 4- Acetylpyridine, Aniline, Benzonitrile, Acetophenone, Methyl Benzoate and Trichloroethylene.
The standards chosen had a log Pow between 0.5 - 2.4.
Results on the test item in solvent mixture (MeOH:H2O - 50:50) at pH 7.5
Average logPow = 1.291
Agreement S1-S2 = 0.002
Tests performed in 20 mM monobasic sodium phosphate buffer at pH 7.5 confirm the data obtained.
DEVIATIONS
No deviations were recorded during the study.
CONCLUSIONS
The partition coefficient (n-octanol/water) of the test item was determined according to "OECD 117-
Partition Coefficient (n-octanol/water), High Performance Liquid Chromatography (HPLC) Method". The partition coefficient (n-octanol/water) proved to be 1.29.
Applicant's summary and conclusion
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