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Diss Factsheets
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EC number: 208-655-6 | CAS number: 537-01-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The test of skin sensitisation in guinea pigs was carried out according to O.E.C.D. guideline No. 406, Directive 67/548/EEC, Annex V, test method B6 and in compliance with Good Laboratory Practices. Fifteen female Dunkin/Hartley guinea-pigs were included in this study. Ten animals were used for the test article and 5 for the control, respectively. Induction was carried out in 2 phases: - Phase 1: Day 1, animals were injected by the intradermal route with Cerium carbonate (25 % w/w in purified water) +/- Freund Complete Adjuvant or with the vehicle; - Phase 2: a 48 hours topical occlusive application was performed Day 8 with Cerium carbonate at 50 % w/w in purified water or the vehicle. The control and test animals were challenged topically 2 weeks after the topical induction application with Cerium carbonate at 25 % w/w in purified water for 24 hours. The challenge sites were evaluated 24 and 48 hours after removal of the patches. The reactions were graded for erythema and oedema according to a numerical scale. No clinical signs and no deaths, related to treatment, were noted during the study. No cutaneous reactions were observed after challenge application.
From the results obtained, Cerium carbonate is not classified as a skin sensitiser according to Annex VI of the Directive 67/548/EEC.
Migrated from Short description of key information:
Based on the results of the only available (and reliable) study, the test substance is not considered as skin sensitiser.
Justification for classification or non-classification
Based on the results of a study performed according to OECD test guideline 406, dicerium tricarbonate does not need to be classified as skin sensitising according to Annex VI of the Directive 67/548/EEC and UN/EU GHS classification system.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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