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EC number: 207-306-5 | CAS number: 460-19-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral exposure is not possible due to physicochemical properties of ethanedinitrile.
Dermal exposure- no adverse effect observed
Inhalation exposure - according CLP - Acute tox. 2; H220
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because a study on acute toxicity by the inhalation route is available
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- >= 136.46 - <= 136.46 ppm air
- Physical form:
- inhalation: gas
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Additional information
Table 8.7.2.-1: Ethanedinitrile acute inhalation toxicity |
Study - inhalatory |
Test organism |
Dose (ppm)/ exposure time (minutes) |
Mortality ratio (dead/dosed) |
Report References |
Nose-only exposure |
Rat (male and female) |
63.14 /4h |
0/10 |
Product Safety Lab 2017 |
128.02 /4h |
1/5 |
|||
181.56 /4h |
6/10 |
|||
Inhal exposure |
Rat |
4,000 / 7.5 |
3/6 |
McNerney and Schrenk 1960 |
4,000 / 15 |
6/6 |
|||
2,000 / 7.5 |
0/6 |
|||
2,000 / 15 |
6/6 |
|||
1,000 / 15 |
0/6 |
|||
1,000 / 30 |
6/6 |
|||
500 / 30 |
0/6 |
|||
500 / 45 |
6/6 |
|||
400 / 45 |
0/6 |
|||
400 / 60 |
6/6 |
|||
250 / 60 |
0/6 |
|||
250 / 120 |
4/6 |
|||
control |
0/6 |
|||
Inhal exposure |
Frog |
8,000 / 1
|
Fatal within 1 day |
Flury and Zernik 1931 |
10,000 / 3 |
Fatal within 30 min |
|||
Mouse |
235 / 15 |
Recovered |
||
2,600 / 12 |
Fatal |
|||
15,000 / <1 |
Fatal |
|||
Rabbit |
100 / 4 hours |
Almost without effect |
||
200 / 4 hours |
Slight symptoms |
|||
300 / 3.5 hours |
Serious symptoms, died later |
|||
400/ 105 |
Fatal |
|||
Cat |
50 / 4 hours |
Serious symptoms but recovered |
||
75 / 4 hours |
Fatal within 2 days of exposure |
|||
100 / 2–3 hours |
Fatal |
|||
200 / 30 |
Fatal |
|||
2,000 / 13 |
Fatal |
Justification for classification or non-classification
Oral exposure is not possible due to physicochemical properties of ethanedinitrile.
Dermal exposure- no adverse effect observed
Inhalation exposure - according CLP - Acute tox. 2; H220
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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