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EC number: 207-306-5 | CAS number: 460-19-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endocrine disrupter mammalian screening – in vivo (level 3)
Administrative data
- Endpoint:
- endocrine disrupter mammalian screening – in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
Materials and methods
Test material
- Reference substance name:
- Oxalonitrile
- EC Number:
- 207-306-5
- EC Name:
- Oxalonitrile
- Cas Number:
- 460-19-5
- Molecular formula:
- C2N2
- IUPAC Name:
- carbononitridic cyanide
- Test material form:
- gas
Constituent 1
- Specific details on test material used for the study:
- 99%
Test animals
- Species:
- other: Rhesus monkey (Macacca mulatta), rat (Sprague-Dawley)
- Sex:
- male
- Details on test animals and environmental conditions:
- 5 monkeys/exp. group
30 rats/exp. group
Administration / exposure
- Route of administration:
- other: inhalation
- Details on route of administration:
- Ethanedinitrile, 11 and 25 ppm, 6 months exposure, whole body exposure
Doses / concentrationsopen allclose all
- Dose / conc.:
- 0 ppm
- Dose / conc.:
- 11 ppm
- Dose / conc.:
- 25 ppm
- No. of animals per sex per dose:
- 5 monkeys
30 rats
Results and discussion
- Endocrine disrupting potential:
- negative
Results of examinations
- Clinical biochemistry findings:
- no effects observed
- Description (incidence and severity):
- No relevant changes in triiodothyronine and thyroxine blood levels
Applicant's summary and conclusion
- Conclusions:
- The active substance is not endocrine disruptor in respect to regulation EC 528/2012. The 6 months study in rats and monkeys revealed no adverse effect relevant for human health, as a change in the morphology, physiology, or, life span of organisms, that would result in an impairment of functional capacity, an impairment of the capacity to compensate for additional stress, or an increase in susceptibility to other influences. Further the study did not reveal an endocrine mode of action or the adverse effect relevant for human health as a consequence of the endocrine mode of action. There was no significant change in the measured blood levels of the thyroid hormones, triiodothyronine (T3) and its prohormone, thyroxine (T4), in exposed animals compared to control, or any pathological effect found on endocrine organs. There is no study reporting the endocrine disruption caused by ethanedinitrile.
- Executive summary:
The active substance is not endocrine disruptor in respect to regulation EC 528/2012. The 6 months study in rats and monkeys revealed no adverse effect relevant for human health, as a change in the morphology, physiology, or, life span of organisms, that would result in an impairment of functional capacity, an impairment of the capacity to compensate for additional stress, or an increase in susceptibility to other influences. Further the study did not reveal an endocrine mode of action or the adverse effect relevant for human health as a consequence of the endocrine mode of action. There was no significant change in the measured blood levels of the thyroid hormones, triiodothyronine (T3) and its prohormone, thyroxine (T4), in exposed animals compared to control, or any pathological effect found on endocrine organs. There is no study reporting the endocrine disruption caused by ethanedinitrile.
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