Registration Dossier
Registration Dossier
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EC number: 205-702-2 | CAS number: 147-85-3
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
L-proline is rapidly oxidized in activated sludge. This leads to the conclusion that it does not show toxic effects to the microorgnism population of activated sludges.
Key value for chemical safety assessment
Additional information
L-proline did not show significant toxic effects to the popoulation of microrganisms in waste water (activated sludge) at a nominal concentration of 500 mg/l. Further, in another not well documented study 18 amino acids were examined for biodegradability and toxic degradation inhibition. In this study L-proline in a concentration of approx. 200 mg/l shows a negligible inhibition (2%) according to Offhaus. L-proline is readily biodegradable.
In accordance with REACH Annex VIII, No. 9.1.4 column 2, the toxicity test to microorganisms does not need to be conducted as there are mitigating factors indicating that the microbial toxicity is unliekly to occur as well as because the substance is readily biodegradable.
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