Registration Dossier
Registration Dossier
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EC number: 205-598-9 | CAS number: 143-29-3
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The potential of hexaoxatricosane to cause skin sensitization was tested in GLP compliant Buehler Test according to OECD test guidelines 406 (Longobardi, 2004). During the induction phase twenty female guinea pigs were exposed epicutaneously to the undiluted test substance. Challenge was performed with the 75% test substance in sterile water, and no skin reaction was observed 24 or 48 hours following exposure.
A comparable result was obtained in a modified Buehler test in guinea pigs when undiluted hexaoxatricosane was applied during both, induction and challenge phase (Kuklinski, 1991).
No human information is available.
Migrated from Short description of key information:
Guinea pig, Buehler test: not skin sensitising (GLP, OECD 406, Longobardi 2004)
Respiratory sensitisation
Endpoint conclusion
- Additional information:
No information available.
Migrated from Short description of key information:
no information available
Justification for classification or non-classification
Based on the available data on the skin sensitization of hexaoxatricosane no classification is warranted according to the criteria of both, 67/548/EEC and CLP regulation (EC) 1272/2008.
Furthermore, there is no information on potential of hexaoxatricosane respiratory sensitisation
, thus no classification is warranted according to the criteria of both, 67/548/EEC and CLP regulation (EC) 1272/2008.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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