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Diss Factsheets
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EC number: 204-605-2 | CAS number: 123-15-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The LD50/LC50 values derived from the key-studies were: LD50 (oral, rat) > 5000 mg/kg bw and LC50 (rat, inhal.) > 8.4 g/m³.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 8 400 mg/m³ air
Additional information
Acute toxicity: oral
The acute oral toxicity of 2-Methylpentanal in the rat was examined according to OECD TG 423 and GLP (ARC, 2008).Two groups of 3 female rats were treated at a dose of 2000 mg/kg bw by oral gavage. During the 14-day observation period neither mortality nor clinical signs were noted. Body weight development was not impaired and no changes were observed at necropsy. As no mortality occurred at 2000 mg/kg bw a LD50 > 5000 mg/kg bw can be assumed acc. to OECD TG 423. This is supported by an older oral toxicity study in the rat (BASF AG, 1977) where a LD50 of ca. 6400 mg/kg bw was determined.
Acute toxicity: inhalation
In an acute inhalation study following the principles of OECD TG 403 groups of 10 rats per sex were whole body exposed to 8.4 mg 2-Methylpentanal/L (analytically measured) for 4 h and subsequently observed for 14 days (BASF AG, 1978). All animals survived. As clinical signs accelerated respiration, crusted noses and rough fur occurred. No animal showed any abnormal finding at necropsy. Body weight development was not impaired.
Consequently, a LC50 > 8.4 mg/L air was determined. In a supporting study no mortality of rats was observed in an atmosphere enriched with the test substance at 20 °C (vapor) after an exposure of 8 hours (BASF, 1977).
Justification for classification or non-classification
Based on the results for acute oral (LD50 rat > 5000 mg/kg bw) and inhalation toxicity (LC50 > 8.4 mg/L), 2-Methylpentanal is not subject for classification according to Directive 67/548/EEC and Regulation 1272/2008/EC.
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