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Diss Factsheets
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EC number: 204-129-5 | CAS number: 116-16-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 1987
Materials and methods
- Principles of method if other than guideline:
- Hydrolyses at different pH buffer and temperature followed by a gas liquid chromatograph analysis with ECD
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Hexachloroacetone
- EC Number:
- 204-129-5
- EC Name:
- Hexachloroacetone
- Cas Number:
- 116-16-5
- Molecular formula:
- C3Cl6O
- IUPAC Name:
- hexachloropropan-2-one
- Test material form:
- not specified
- Details on test material:
- The chemical hexachloroacetone (HCA), were purchased from Tokyo-Kasei Co. Tokyo of Japan.
In the first experiment, 4 kinds of buffer solutions which had pH 4.0 (0.2M, acetate), pH 6.0 and 7.0 (0.2M, phosphate), and pH 8.0 (0.2 M, Tris-HCl) were used as test solutions.
In the second experiment, sea water (pH 8.0, COD= 1.0 mg/L), effluents A (pH 4.3, COD= 148.3 mg/L) and B (pH 6.1, COD= 49.4 mg/L) from a kraft pulp mill were employed for test solutions.
Constituent 1
- Radiolabelling:
- no
Study design
- Buffers:
- 4 kinds of buffer solutions which had pH 4.0 (0.2M, acetate), pH 6.0 and 7.0 (0.2M, phosphate), and pH 8.0 (0.2 M, Tris-HCl) were used as test solutions.
- Details on test conditions:
- A dioxane solution of HCA was mixed with a 5 ml of test solution in each test tube and kept for 0 - 48 h. After an appropriate time, 5 ml of n-hexane for HCA followed by 2 g of NaCl were added and the residual chloroacetone was extracted by repeating 8 times of 30 sec shaking. An extract was diluted with the same solvent to an appropriate concentration and was analyzed by a gas-liquid chromatograph equipped with an electron capture detector. The running conditions were as follows:
instrument, Shimadzu GC-4CM; column, 2% silicone OV-17 (id 2mm x 2m); column temperature 120°C (HCA); injection and detector temperature, 210°C; carrier gas, N2, 40 mL/min.
The retention times HCA were 2.9 min, 5.4 min and 4.0 min, respectively. The content of hexachloroacetone was calculated from the calibration curve.
These experiments were done in the dark (shielding light with an aluminum foil) or under the sun-lamp (270-440 nm, max 320 nm) at different temperatures (0°C, 15°C, 40°C). The extraction efficiency of each organic solvent to hexachloroacetone was 95 ±2% in the preliminary experiment.
Duration of test
- Duration:
- 48 h
- Initial conc. measured:
- 10 mmol/L
Results and discussion
- Details on results:
- Extraction sufficiency was 95 +-2 %
Any other information on results incl. tables
HCA was extremely unstable compound even in the acidic conditions. It entirely disappeared within 6 h except the reaction at pH 4.0 (0°C). The residual ratio of HCA in the solution (pH 4.0, 0°C) was 70%after 24 h. The photo-irradiation also accelerated the degradation ratio of HCA. In this experiment, dioxane was used as a solvent because of the lability of HCA in an acetone solution. The similar solvent interaction of HCA was also observed by other investigators.
It was found that the degradation ratio of the chloroacetone which show mutagenic activity was depend upon the reaction pH and temperature, but not so much on the light. It was also found that the increase of the number of chlorine atoms in the molecule cause the decrease of the stability of the chloroacetone.
In the second experiment, the degradation efficiency of the chloroacetone was examined in the environmental samples such as coastal sea water (pH 8.0), kraft pulp mill effluents A (pH 4.3) and B (pH 6.1) in the dark. HCA disappeared immediately during the incubation in sea water. HCA was very fragile and it disappeared within 2 h in three water samples. The degradation of HCA in the environmental samples was consistent with that observed in buffer solutions. These results are compatible with a report in which 2-chloropropenal in acidic solution is more stable than in a basic solution.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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