Registration Dossier
Registration Dossier
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EC number: 203-963-7 | CAS number: 112-36-7
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
As suggested by physicochemical properties and confirmed by toxicity or toxicokinetics studies performed with the diethylene glycol monoalkyl and dialkyl ether category members, DEGDEE is readily absorbed via all routes of exposure and is distributed in most biological tissues. The metabolism of DEGDEE is expected to be very similar to DEGDME’s since they both have alcohol groups etherified with alkyl groups (methyl or ethyl). DEGDEE is metabolised by cleavage of the ether bonds by monooxygenase to form an alkoxyethoxyethanol or to a lesser extent an alkoxyethanol ( which are then oxidised by the alcohol and aldehyde dehydrogenase into alkoxyethoxyacetic acids (EEAA) and alkoxyacetic acids (EAA) (ECETOC TR 95, 2005). Diethylene glycol dialkyl ethers metabolism appears to be increased by repeated administration due to liver enzyme induction (ECETOC TR95, 2005). Excretion of DEGDEE and its metabolites is primarily in the urine via the kidneys.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 100
- Absorption rate - inhalation (%):
- 100
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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