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EC number: 203-757-7 | CAS number: 110-33-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
Description of key information
LC50 (14d) > 800 mg/kg for Eisenia fetida (read across to Dibutyl adipate CAS 105-99-7 and Bis(2-ethylhexyl) adipate CAS 103-23-1)
Key value for chemical safety assessment
Additional information
No study on the toxicity of Dihexyl adipate (CAS 110 -33 -8) to earthworm is available. Therefore, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 Grouping of substances, a read-across to the structurally related category members Dibutyl adipate (CAS 105-99-7) and Bis(2-ethylhexyl) adipate (CAS 103-23-1) was conducted. Further justification is given within the endpoint summary 6.1 and within the category justification section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance within this category was used.
The study conducted with Dibutyl adipate (CAS 105-99-7) was performed as a limit test according to OECD guideline 207 and GLP (Moser, 2013). The test organism Eisenia fetida was exposed to the test substance in artificial soil for 14 days, at the nominal test concentration 1000 mg/kg. No mortality occurred during the test period. Hence, the 14d LC50 was assessed as > 1000 mg/kg soil dw.
The study conducted with Bis(2-ethylhexyl) adipate (CAS 103-23-1) was performed according to EU method C.8 and GLP (Huels, 1996). The test organism Eisenia fetida was exposed to the test substance in artificial soil for 14 days, at nominal test concentrations of 171, 301, 550, 1000 mg/kg dw. The 14d LC50 was determined to be 865 mg/kg soil dw.
Due to the structural and property similarities with the tested category members Dibutyl adipate (CAS 105-99-7) and Bis(2-ethylhexyl) adipate (CAS 103-23-1) this result is also applicable to read across to Dihexyl adipate (CAS 110-33-8).
According to ECHAs Guidance R.7c, the absence of chronic or long-term effects in aquatic organisms up to the substance solubility limit, can be used as part of a Weight of Evidence argument to modify/waive the data requirements of Annex IX and X. For the category PFAE linear, there are three chronic tests on aquatic invertebrates available for insoluble category members (i.e. CAS 103-23-1 Bis(ethylhexyl)adipate; CAS 33703-08-1 Diisononyl adipate and CAS 103-24-2 Nonanedioic acid, bis(2-ethylhexyl) ester). These substances exhibit log Kow values > 5 and a water solubility < 0.05 mg/L. In none of these tests effects on Daphnia were observed in nominal concentrations well above the limit of water solubility. Therefore, it is assumed that chronic tests on terrestrial organisms will not result in a different outcome.
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