Registration Dossier
Registration Dossier
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EC number: 200-822-1 | CAS number: 74-93-1
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.76 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 25
- Modified dose descriptor starting point:
- NOAEC
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Additional information - workers
Long-term inhalation exposure - systemic affects
The NOAEC for systemic toxicity was 17 ppm in a 13 -week toxicity study (Tansy et al., 1981).
Step 1) Relevant dose-descriptor
* NOAEC rat, 7 hours/day, 5 days/week = 17 ppm
Step 2) Modification of starting point:
* Correction of exposure duration in study (7 hrs/day, 5 days/week) to default worker exposure (8 hrs/day, 5 days/ week)
* Correction for activity driven differences of respiratory volumes in workers compared to workers in rest: 6.7 m3/10 m3
Step 3) Assessment factors
* Interspecies: 2.5
For inhalation studies only a factor 2.5 is used, and no correction is made for differences in body size, because extrapolation is based on toxicological equivalence of a concentration of a chemical in the air of experimental animals and humans; animal and humans breathe at a rate depending on their caloric requirements.
* Intraspecies : 5
* Exposure duration :2
* Dose response:1
* Quality of database:1
DNEL Value based on NOAEC 13-w/rats :
17 x 7/8 x 5/7 x 6.7/10 x 1/(2.5 x 5 x 2 x 1 x 1) =0.39 ppm (0.76 mg/m3)
General Population - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
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