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Diss Factsheets
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EC number: 200-699-4 | CAS number: 68-96-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Flammability
Administrative data
Link to relevant study record(s)
- Endpoint:
- self-heating substances / mixtures
- Remarks:
- pyrophoric properties
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- UN Manual of Tests and Criteria: Test N.4 (Test method for self-heating substances)
- Deviations:
- no
- GLP compliance:
- no
- Other quality assurance:
- ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
- Key result
- Test procedure:
- other: UN-N.4: 16 mL and 1000 mL test volume at 138 and 139 °C
- Max. temp. reached:
- 139
- Induction time (h):
- 24
- Result:
- negative outcome (no effect observed)
- Remarks on result:
- other: The sample in its delivery state was tested.
- Interpretation of results:
- not classified based on GHS criteria
- Conclusions:
- Hydroxyprogesteron is a not self heating substance and has no pyrophoric properties and is in the sense of the CLP-Directive a non-pyrophoric solid.
- Executive summary:
Hydroxyprogesteron is a not self heating substance and has no pyrophoric properties and is in the sense of the CLP-Directive a non-pyrophoric solid.
- Endpoint:
- flammable solids
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2001
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.10 (Flammability (Solids))
- Deviations:
- no
- GLP compliance:
- no
- Key result
- Test procedure:
- burning rate test: preliminary screening test
- Remarks:
- mould with triangular cross section according to EU method A.10
- Moisture (wt %):
- 0.07
- Remarks on result:
- other: The substance should not be considered as highly flammable and no further testing (burning rate test) is required
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Hydroxyprogesteron is not to be considered as highly flammable.
- Executive summary:
The flammability was determined according to the Directive 'Classification, packaging and labeling of dangerous substances in the European Union, Part 2' testing method A.10. Hydroxyprogesteron should not be considered as highly flammable and no further testing is required.
- Endpoint:
- substances / mixtures which in contact with water emit flammable gases
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the organic substance does not contain metals or metalloids and hence, the classification procedure does not need to be applied
Referenceopen allclose all
Description of key information
a.) Flammability: Hydroxyprogesteron is a non-flammable solid according to EU method A.10.
b.) Pyrophoric properties: Hydroxyprogesteron did not deliver indications of pyrophoric properties during the realization of other tests. The determination according to UN-MTC Procedure N.2 is not necessary.
c.) Contact with water: A review of the structure suggests that there are no chemical groups present that would imply pyrophoric properties or flammability on contact with water. A review of handling and use implies no pyrophoric properties or flammability on contact with water. Testing according to UN Procedure N.5 is not necessary.
d.) Self-heating substances: Hydroxyprogesteron is not a self-heating substance according to UN-N.4.
Key value for chemical safety assessment
- Flammability:
- not classified
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.