Adenosine phosphate

Flammability

Administrative data

Endpoint:

self-heating substances / mixtures

Type of information:

experimental study

Adequacy of study:

key study

Study period:

12 - 13 April 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2017

Report date:

2017

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

other: UN Recommendations on the TRANSPORT OF DANGEROUS GOODS: Manual of Tests and Criteria

Version / remarks:

Rev. 6 (2015)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

other: VDI 2263 Sheet 1 Grewer Oven

Version / remarks:

1990

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Test material

Test material information

Constituent 1

Reference substance name:

Adenosine phosphate

EC Number:

200-500-0

EC Name:

Adenosine phosphate

Cas Number:

61-19-8

Molecular formula:

C10H14N5O7P

IUPAC Name:

adenosine phosphate

impurity 1

Reference substance name:

Water

EC Number:

231-791-2

EC Name:

Water

Cas Number:

7732-18-5

Molecular formula:

H2O

IUPAC Name:

Oxidane

Test material form:

solid: crystalline

Remarks:

crystalline powder

Details on test material:

Batch No: 11679700
Storage: at room temperature, protected from light

Results and discussion

Self-heating substances / mixtures

Self-heating substances / mixtures 1

Key result

Test procedure:

other: Grewer oven

Remarks:

pure test item

Max. temp. reached:

195

Result:

other: no significant temperature increase was observed starting at 175°C

Remarks on result:

other: on the basis of the results, the test item cannot be classified. Further tests are needed.

Self-heating substances / mixtures 2

Key result

Test procedure:

other: Grewer oven

Remarks:

test item in mixture with Kieselguhr

Max. temp. reached:

200

Result:

other: no significant temperature increase was observed starting at 175°C

Remarks on result:

other: on the basis of the results, the test item cannot be classified. Further tests are needed.

Self-heating substances / mixtures 3

Key result

Test procedure:

other: Grewer oven

Remarks:

test item in mixture with Kieselguhr

Max. temp. reached:

425

Result:

other: no significant temperature increase was observed starting at 310°C

Remarks on result:

other: on the basis of the results, the test item cannot be classified. Further tests are needed.

Any other information on results incl. tables

In the investigation of self-ignition in the Grewer Oven for the pure test item an endothermic effect could be observed in the temperature range of 100 – 150 °C, which can be assigned to a drying of the test item. A small exothermic process was detected starting at 175 °C. This self-heating did not lead to a significant temperature increase (15 °C above the corresponding temperature of the reference material). During the decomposition process, the test item expanded, welled out of the basket and a black residue remained after the test.

For the test item in mixture with Kieselguhr an endothermic effect could be observed in the temperature range of 100 – 130 °C, which can be assigned to a drying of the test item. A small exothermic effect was detected starting at 175 °C, which also did not lead to a significant temperature increase (15 °C above the corresponding temperature of the reference material). A second exothermic effect was detected starting at 310 °C, which only lead to a temperature increase of approx. 10 °C above the corresponding temperature of the reference material. In this test, the test item also expanded, welled out of the basket.

Applicant's summary and conclusion

Interpretation of results:

study cannot be used for classification

Conclusions:

The pure test item Adenosine-5'-monophosphate (AMP) (CAS no. 61-19-8) indicated a self-heating at atmospheric pressure starting at a temperature of 175 °C. This self-heating process did not lead to a significant temperature increase, since the test item expanded and welled out of the wire basket.
On the basis of the results of the tests on the self-ignition in the Grewer Oven according to the UN Recommendations on the TRANSPORT OF DANGEROUS GOODS: Manual of Tests and Criteria, Appendix 6 Division 4.2, a classification of the test item as self-heating substance cannot be excluded. Further tests have to be performed for the classification.

Executive summary:

The pure test item Adenosine-5'-monophosphate (AMP) (CAS no.61-19-8) indicated a self-heating at atmospheric pressure starting at a temperature of 175 °C. This self-heating process did not lead to a significant temperature increase, since the test item expanded and welled out of the wire basket.

On the basis of the results of the tests on the self-ignition in the Grewer Oven according to the UN Recommendations on the TRANSPORT OF DANGEROUS GOODS: Manual of Tests and Criteria, Appendix 6 Division 4.2, a classification of the test item as self-heating substance cannot be excluded. Further tests have to be performed for the classification.