Registration Dossier
Registration Dossier
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EC number: 200-273-8 | CAS number: 56-41-7
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
It can be concluded that L-alanine is rapidly oxidized in activated sludge. This leads to the conclusion that it does not show toxic effects to the microorgnism population of activated sludges.
Key value for chemical safety assessment
Additional information
DL-Alanine did not show significant toxic effects to the population of microrganisms in waste water (activated sludge) at a nominal concentration of 500 mg/l. Read-across from DL-alanine to L-alanine was applied because of similar physico-chemical characteristics, a similar toxicological/ecotoxicological profile and the structural similarity of racemic alanine to the enantiomer L-alanine. One can expect that the equivalent concentrations of L-alanine will not show toxic effects in this test system. Instead of DL-alanine, L-alanine is a natural constituent of most living cells, is involved in many metabolic pathways and more subject to undergo biodegradation.
Further, in another not well documented study 18 amino acids were examined for biodagradability and toxic degradation inhibition. In this study L-alanine in a concentration of approx. 208 mg/l shows no toxic inhibition (0%) according to Offhaus.
The summation of results leads to the conclusion that L-alanine is readily biodegradable.
In accordance with REACH Annex VIII, No. 9.1.4 column 2, the toxicity test to microorganisms does not need to be conducted as there are mitigating factors indicating that the microbial toxicity is unlikely to occur as well as because the substance is readily biodegradable.
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