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EC number: 700-054-1 | CAS number: 70905-68-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The test was carried out in accordance with the OECD Guideline for Testing of Chemicals No. 301 F.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-D (Determination of the "Ready" Biodegradability - Manometric Respirometry Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Swiss Federal Department of the Interior
Test material
- Reference substance name:
- (1S,4R,6R)-1-[(3E)-5-hydroxy-3-methylpent-3-en-1-yn-1-yl]-2,2,6-trimethylcyclohexane-1,4-diol
- EC Number:
- 700-054-1
- Cas Number:
- 70905-68-9
- Molecular formula:
- C15H24O3
- IUPAC Name:
- (1S,4R,6R)-1-[(3E)-5-hydroxy-3-methylpent-3-en-1-yn-1-yl]-2,2,6-trimethylcyclohexane-1,4-diol
- Reference substance name:
- (1S,4R,6R)-1-[(E)-5-Hydroxy-3-methyl-3-penten-1-ynyl]-2,2,6-trimethyl-1,4-cyclohexanediole
- IUPAC Name:
- (1S,4R,6R)-1-[(E)-5-Hydroxy-3-methyl-3-penten-1-ynyl]-2,2,6-trimethyl-1,4-cyclohexanediole
- Details on test material:
- - Name of test material (as cited in study report): Triol
- Physical state: white solid
- Analytical purity: 99.5 % (LC), 99.8 % (DSC)
- Lot/batch No.: 6262/ZTN/03/N/08/001/003
- Expiration date of the lot/batch: 1 December 2000
- Stability under test conditions: not specified in water
- Storage condition of test material: in refridgerator at 4 +/- 3 °C, protected from sunlight
- Other:
Constituent 1
Constituent 2
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): Wastewater treatment plant ARA Ergolz II, Füllinsdorf, Swtizerland
- Laboratory culture:
- Method of cultivation:
- Storage conditions: aerated at room temperature
- Storage length:
- Preparation of inoculum for exposure:
- Pretreatment:
- Concentration of sludge: 1 g/L (dry weight basis), which was then diluted to give a final concentration in the inoculum of 30 mg dry weight per liter
- Initial cell/biomass concentration:
- Water filtered: yes/no
- Type and size of filter used, if any: - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
- Composition of medium: a) 8.5 g KH2PO4, 21.75 g K2HPO4, 33.4 g Na2HPO4 x 2 H2O, 0.5 g NH4Cl dissolved in purified water and made up to 1000 mL (pH 7.4); b) 22.5 g MgSO4 x 7 H2O dissolved in purified water and made up to 1000 mL; c) 36.4 g CaCl2 x 2H2O dissolved in purified water and made up to 1000 mL; d) 0.25 g FeCl3 X 6 H2O dissolved in purified water and made up to 1000 mL (in order to avoid having to prepare this solution immediately before use, a drop of concentration HCl per liter was added). The final test water was obtained by mixing 10 mL of solution a) and 1 mL each of solutions b)-d) and making up to 1000 mL with purified water. pH was adjusted to 7.4 with a diluted hydrochloric acid solution.
- Additional substrate:
- Solubilising agent (type and concentration if used):
- Test temperature: 22 °C
- pH: 7.4 at the start of the test
- pH adjusted: yes
- CEC (meq/100 g):
- Aeration of dilution water:
- Suspended solids concentration: 30 mg dry material per liter
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus:
- Number of culture flasks/concentration: two
- Method used to create aerobic conditions: electrolytically generated oxygen from a copper sulfate solution
- Method used to create anaerobic conditions:
- Measuring equipment: electrode type manometer
- Test performed in closed vessels due to significant volatility of test substance:
- Test performed in open system:
- Details of trap for CO2 and volatile organics if used:
- Other:
SAMPLING
- Sampling frequency:
- Sampling method:
- Sterility check if applicable:
- Sample storage before analysis:
- Other:
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes
- Abiotic sterile control: yes
- Toxicity control: yes
- Other: Procedure control
STATISTICAL METHODS:
Reference substance
- Reference substance:
- other: Sodium benzoate
Results and discussion
- Preliminary study:
- The biochemical oxygen demand (BOD) of the test article Triol in the test media was within the range of the inoculum controls. Consequently, Triol was found to be not biodegradable under the test conditions within 28 days.
- Test performance:
- The results with the positive reference substance indicated the suitability of the activated sludge.
% Degradation
- Parameter:
- % degradation (O2 consumption)
- Value:
- 1
- Sampling time:
- 28 d
- Details on results:
- Details are given in Table 1
The biodegradation rate in the toxicty control showed a similar course of biodegradation over the 28 days of exposure as the two procedure controls containing the reference item only. Within 14 days of exposure a biodegradation of 38 % was observed. Thus, according to the test guidelines, the test item had no inhibitory effect on activated sludge microorganisms as the biodegradation rate in the toxicity control was > 25 % after 14 days.
BOD5 / COD results
- Results with reference substance:
- In the procedure controls, the reference item sodium benzoate was degraded by an average of 84 % by exposure day 14, thus confirming the suitability of the activated sludge. At the end of the test (day 28), the reference item was degraded by an average of 89 %.
Any other information on results incl. tables
Table 2: Biodegradation of Triol and the reference item.
Time (days) |
Percentage biodegradation (corrected for inoculum controls) |
||||
Test item |
Procedure control |
Toxicity control |
|||
Flask No. 5 |
Flask No. 6 |
Flask No. 3 |
Flask No. 4 |
Flask No. 8 |
|
0 |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
10 |
7 |
3 |
2 |
1 |
0 |
49 |
49 |
19 |
3 |
0 |
0 |
57 |
57 |
22 |
4 |
- |
- |
- |
- |
- |
5 |
- |
- |
- |
- |
- |
6 |
0 |
0 |
73 |
78 |
33 |
7 |
1 |
0 |
76 |
80 |
33 |
8 |
1 |
0 |
78 |
81 |
34 |
9 |
1 |
0 |
79 |
82 |
35 |
10 |
1 |
0 |
80 |
83 |
35 |
11 |
- |
- |
- |
- |
- |
12 |
- |
- |
- |
- |
- |
13 |
1 |
0 |
82 |
85 |
37 |
14 |
1 |
0 |
83 |
85 |
38 |
15 |
1 |
0 |
83 |
86 |
38 |
16 |
1 |
0 |
84 |
87 |
39 |
17 |
1 |
0 |
84 |
87 |
40 |
18 |
- |
- |
- |
- |
- |
19 |
- |
- |
- |
- |
- |
20 |
1 |
0 |
85 |
88 |
41 |
21 |
1 |
0 |
85 |
88 |
41 |
22 |
1 |
0 |
85 |
88 |
42 |
23 |
1 |
0 |
86 |
89 |
42 |
24 |
2 |
0 |
86 |
89 |
43 |
25 |
- |
- |
- |
- |
- |
26 |
2 |
0 |
87 |
90 |
44 |
27 |
2 |
0 |
87 |
90 |
45 |
28 |
2 |
1 |
88 |
91 |
46 |
Mean (Day 28) |
1 |
89 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- Triol was found to be not biodegradable under the test conditions within 28 days.
- Executive summary:
The test item Triol was investigated for its ready biodegradability in a 28 -day manometric respiratory test based on Commission Directive 92/69/EEC, C.4 -D, 1992, and OECD Guideline No. 301 F, 1992.
The biochemical oxygen demand (BOD) of Triol in the test media was within the range of the inoculum control.
Consequently, Triol was found to be not biodegradable under the test conditions within 28 days.
In the toxicity control, containing both Triol and the reference item sodium benzoate, no inhibitory effect on the biodegradation of the reference item was determined. Thus, Triol had obviously no inhibitory effect on the activity of activated sludge microorganisms.
In the procedure controls, the reference item sodium benzoate was biodegraded by an average of 84 % after two weeks, and reached an average biodegradation rate of 89 % by the end of the tes, thus confirming the suitability of the activated sludge.
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