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Diss Factsheets
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EC number: 203-464-4 | CAS number: 107-12-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
For skin irritation/corrosion, read-across was performed based on 9 category members. No skin irritating properties are expected. Additionally, a reliable handbook reference is available that reports no evidence for skin irritation.
Based on these two elements, propionitrile is consided not irritating to the skin.
For eye irritation, read-across was performed based on 9 category members. The read-across did not predict eye irritation properties but it should be noted that two closely related substances in the database were classified for eye irritation (Cat 2). Additionally, a reliable handbook reference is available that reports mildly irritating effects on the eye.
Based on this information, propionitrile can be irritating to the eyes and therefore propionitrile was classified as Eye Irrit 2.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- No further details are provided but this study has been peer reviewed by the US National Institute for Occupational Safety and Health (NIOSH) and is therefore considered a credible source.
- GLP compliance:
- not specified
- Species:
- rabbit
- Basis:
- mean
- Time point:
- 24 h
- Remarks on result:
- positive indication of irritation
- Remarks:
- Mild irritation of the skin was observed after 24 hours at a dose of 500 mg proprionitrile
- Interpretation of results:
- Category 3 (mild irritant) based on GHS criteria
- Conclusions:
- Moderate effects on the eyes of rabbits were observed after 24 hours at a dose of 100 mg.
- Endpoint:
- skin irritation: in vivo
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- REPORTING FORMAT FOR THE CATEGORY APPROACH
See attached documentation - Qualifier:
- according to guideline
- Guideline:
- other: Guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals
- Remarks on result:
- no indication of irritation
- Remarks:
- Based on read-across from 8 category members
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the read-across from closely related substances (unbranched nitriles), propionitrile is not expected to cause skin irritation or corrosion.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- No further details are provided but this study has been peer reviewed by the US National Institute for Occupational Safety and Health (NIOSH) and is therefore considered a credible source.
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Irritation parameter:
- other:
- Basis:
- mean
- Time point:
- 24 h
- Remarks on result:
- positive indication of irritation
- Remarks:
- Moderate effects were observed at a dose of 100 mg
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- Moderate effects on the eyes of rabbits were observed after 24 hours at a dose of 100 mg.
- Endpoint:
- eye irritation: in vivo
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- REPORTING FORMAT FOR THE CATEGORY APPROACH
See attached documentation for a detailed description of the read-across approach. - Qualifier:
- according to guideline
- Guideline:
- other: Guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals
- Remarks on result:
- no indication of irritation
- Remarks:
- Based on a read-across from 8 category members
- Remarks on result:
- other: Acetonitrile and oxalonitrile are two category members that have a very similar log Kow and that are considered irritating to the eyes. Although no eyeye irritation is predicted based on all 8 category members, it cannot be excluded based on these two.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the read-across from 8 category members (unbranched nitriles), no eye irritation is predicted for propionitrile.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.