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EC number: 231-601-8 | CAS number: 7647-18-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Health surveillance data
Administrative data
- Endpoint:
- health surveillance data
- Type of information:
- other: human case report
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Reasonably well-documented case report.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- other: case report
- Title:
- The work of an occupational hygiene service in environmental control
- Author:
- McCallum R.I.
- Year:
- 1 963
- Bibliographic source:
- Ann Occup Hyg. Vol. 6, pp. 58-64. Pergamon Press Ltd., 1963
Materials and methods
- Study type:
- health record from industry
- Endpoint addressed:
- skin irritation / corrosion
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Men working at a plant near Newcastle in United Kingdom with the production of antimony oxide and the pure metal from sulphide ore by various smelting processes were radiographed. The examination was performed by the occupational hygiene service .
- GLP compliance:
- no
- Remarks:
- not applicable
Test material
- Reference substance name:
- Diantimony trioxide
- EC Number:
- 215-175-0
- EC Name:
- Diantimony trioxide
- Cas Number:
- 1309-64-4
- Molecular formula:
- Sb2O3
- IUPAC Name:
- dioxodistiboxane
- Test material form:
- not specified
Constituent 1
Method
- Type of population:
- occupational
- Ethical approval:
- not specified
- Details on study design:
- - examination of workers and retired workers especially x-ray of the lungs
Results and discussion
- Results:
- The rash consisted of papules and pustules around sweat and sebacous glands. It affected particularly the fore arms and thighs and the flexures and did not appear on the face, hands or feet. The spots disappeared rapidly over a weekend or public holiday, but reappeared on return to work.
Over hundred men were employed but the frequency of dermatitis was not stated.
Any other information on results incl. tables
Further results:
- a number of men working on this antimony plant at present have symptomless lung changes on radiographic examination
(first noticed in another investigation)
- Observation did not show any alteration in the radiological opacities, but:
2 men developed tuberculosis lesions (which responded promptly to chemotherpy)
- one man with pneumoconiosis who had respiratory symptoms had chronic bronchitis with respiratory obstruction
- men exposed to antimony excrete it in their urine
- examination of urine sample of 3 men with lung changes showed: 425, 480 and 680 µg/l
- in a men with pneumoconiosis who retired at the age of 65 years urine level was 55 µg/l 7 month later and 28 µg/l 4 years later
(there was no detectable diminution in the lung changes over this period)
This study indicates that work in various smelting processes in the production of antimony trioxide and pure metal is connected with dermatitis in warm weather.
Applicant's summary and conclusion
- Conclusions:
- This study indicates that work in various smelting processes in the production of diantimony trioxide and the pure metal is connected with dermatitis in warm weather.
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