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Physical & Chemical properties

Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 2018-05-23 to 2018-12-04
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
effusion method: vapour pressure balance
Key result
Test no.:
#1
Temp.:
20 °C
Vapour pressure:
0 Pa
Test no.:
#2
Temp.:
25 °C
Vapour pressure:
0 Pa
Test no.:
#3
Temp.:
50 °C
Vapour pressure:
0.006 Pa

Effusion method: Vapour pressure balance

The vapour pressure was measured in the temperature range of 37 to 63 °C. The measured vapour pressure values together with the measured temperatures are listed below:

 

Results of the Effusion method

No.

Temperature / °C

Vapour pressure / Pa

1

37

1.17 × 10-3

2

42

2.79 × 10-3

3

47

5.49 × 10-3

4

52

9.60 × 10-3

5

58

1.48 × 10-2

6

63

2.06 × 10-2

 

The vapour pressure of the test item calculated by inter- and extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50 °C is shown below:

 

From the measured data points of the vapour pressure curve the constants A and B of the Antoine equation

log10p = A + B/T = A + B/(C+ϑ)

were derived by regression of the data points to

A = 13.0390

B = -4922.45

C = 273.15

Calculated vapour pressure values for 20, 25 and 50 °C

Temperature / °C

Vapour pressure / Pa

20

1.77 × 10-4

25

3.38 × 10-4

50

6.40 × 10-3

 

Conclusions:
The vapour pressure of the test item was calculated by extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50 °C to be 1.77E-4 Pa, 3.38E-4 Pa and 6.40E-3 Pa, respectively.
Executive summary:

A study was conducted according to OECD TG 104, Regulation (EC) No 440/2008 method A.4 and OPPTS 830.7950 to determine the vapour pressure of the test item. The vapour pressure was measured in the temperature range of 37 to 63 °C using the effusion method (vapour pressure balance). All measured values showed good reproducibility, giving relative standard deviations of less than 25 %, and good correlation. Therefore, the result of the test according to the guideline criteria was considered to be valid. The vapour pressure was calculated using the linear regression equation of the Log P versus 1/T function. The vapour pressure was calculated for the temperatures 20, 25 and 50 °C to be 1.77E-4 Pa, 3.38E-4 Pa and 6.40E-3 Pa, respectively.

Description of key information

The vapour pressure of the test item was calculated by extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50 °C to be 1.77E-4 Pa, 3.38E-4 Pa and 6.40E-3 Pa, respectively.

Key value for chemical safety assessment

Vapour pressure:
0 Pa
at the temperature of:
20 °C

Additional information

A study was conducted according to OECD TG 104, Regulation (EC) No 440/2008 method A.4 and OPPTS 830.7950 to determine the vapour pressure of the test item. The vapour pressure was measured in the temperature range of 37 to 63 °C using the effusion method (vapour pressure balance). All measured values showed good reproducibility, giving relative standard deviations of less than 25 %, and good correlation. Therefore, the result of the test according to the guideline criteria was considered to be valid. The vapour pressure was calculated using the linear regression equation of the Log P versus 1/T function. The vapour pressure was calculated for the temperatures 20, 25 and 50 °C to be 1.77E-4 Pa, 3.38E-4 Pa and 6.40E-3 Pa, respectively (reference 4.6-1).