Registration Dossier
Registration Dossier
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EC number: 259-097-5 | CAS number: 54322-33-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- data is from safety assessment reports
Data source
Reference
- Reference Type:
- secondary source
- Title:
- IUCLID Dataset for the CAS: 110-93-0
- Author:
- EUROPEAN COMMISSION European Chemicals Bureau
- Year:
- 2 000
- Bibliographic source:
- IUCLID Dataset, EUROPEAN COMMISSION European Chemicals Bureau, 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Skin irritation study of Methallyl sulfonate was conducted in 6 male rabbits to determine its irritation potential.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium 2-methylprop-2-ene-1-sulphonate
- EC Number:
- 216-341-5
- EC Name:
- Sodium 2-methylprop-2-ene-1-sulphonate
- Cas Number:
- 1561-92-8
- Molecular formula:
- C4H8O3S.Na
- IUPAC Name:
- sodium 2-methylprop-2-ene-1-sulfonate
- Test material form:
- solid
- Details on test material:
- - Name of test material (as cited in study report): sodium 2–methylprop–2–ene–1–sulphonate
- Molecular formula:C4H8O3S.Na
- Molecular weight : 158.152 g/mol
- Substance type: Organic
- Physical state: Solid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): sodium 2–methylprop–2–ene–1–sulphonate
- Molecular formula:C4H8O3S.Na
- Molecular weight : 158.152 g/mol
- Substance type: Organic
- Physical state: Solid
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- sex: male
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 mL
- Duration of treatment / exposure:
- 24 Hours
- Observation period:
- 48 hours
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: Back
- % coverage: No Data Available
- Type of wrap if used: bandage
REMOVAL OF TEST SUBSTANCE
- Washing (if done): No Data Available
- Time after start of exposure:
No Data Available
SCORING SYSTEM: No Data Available
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: Redness
- Basis:
- mean
- Time point:
- other: 1-2 and 48 hours
- Score:
- 0.17
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 1-2 and 48 hours
- Score:
- 0.25
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- no irritation observed
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- The mean erythema and edema scores after 1-2 and 48 hours were 0.17 and 0.25 respectively.
Based on the scores, Methallyl sulfonate (CAS No:- 1561-92-8) was considered to be not irritating to the rabbits’ skin - Executive summary:
The skin irritation study ofMethallyl sulfonate(CAS No:-1561-92-8)was performed in rabbits to determine its irritation potential.0.5 ml of the undiluted test substance was applied to the shaved back skin of 6 male rabbits. After occlusion for 24 hours, the bandage was removed. Skin reactions were scored 1–2 and 48 hours after removal of the bandage.
The mean erythema and edema scores after 1-2 and 48 hours were 0.17 and 0.25 respectively.
Based on the scores, Methallyl sulfonate (CAS No:- 1561-92-8) was considered to be not irritating to the rabbits’ skin
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