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EC number: 203-862-8 | CAS number: 111-36-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Respiratory sensitisation
Administrative data
- Endpoint:
- respiratory sensitisation: in vivo
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No validated and suitable experimental animal model to assess the potential for respiratory sensitization or asthma
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
- Principles of method if other than guideline:
- Guinea pigs were exposed by head only to an aerosol of protein-isocyanate conjugate according to the following procedure: A 5-minute control during which the animals breathed house-line air A 10-minute exposure to an aerosol of protein conjugate A 5-minute recovery period on house-line air Animals were exposed once daily, five days a week. Their chamber positions were rotated every other day to eliminate possible effects of differences in aerosol distribution. Animals were exposed to protein isocyanate conjugate until a positive respiratory response occurred as determined by respiratory index. After a response the animals were challenged the following day with 1.) bovine serum albumin (BSA) alone to confirm that the animal was not responding to the carrier protein; then 2.) guinea pig albumin (GSA)-isocyanate conjugate to verify that the response was to the isocyanate hapten 3.) if no response occurred, the animal was re-exposed to the original BSA-isocyanate conjugate to determine whether it was still responsive to it. Chamber concentration of protein was determined as mg protein per liter air sampled. The degree of isocyanate protein conjugation was determined prior to testing. DATA ANALYSIS: A positive asthmatic response in guinea pigs was characterized by a marked increase in respiration rate. This was followed in some cases by respiratory "collapse"-a violent anaphylactic response caused by contraction of the bronchial smooth musculature resulting in gasping respiration. Both parameters were used to calculate the respiratory index (RI). A positive response was an increase in rate of greater than three standard deviations from the test animal´s average respiratory index of preceding exposure days. A negative respiratory index resulted if rate during or following exposure never exceeded the control rate.
- GLP compliance:
- no
Test material
- Reference substance name:
- Butyl isocyanate
- EC Number:
- 203-862-8
- EC Name:
- Butyl isocyanate
- Cas Number:
- 111-36-4
- Molecular formula:
- C5H9NO
- IUPAC Name:
- 1-isocyanatobutane
- Details on test material:
- IUCLID4 Test substance: other TS: bovine serum albumin (BSA)-butyl isocyanate
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- Hartley
- Sex:
- male
Test system
- Route of induction exposure:
- inhalation
- Route of challenge exposure:
- inhalation
- Vehicle:
- other: serum albumin as carrier
- Concentration:
- BSA-butyl isocyanate (conjugation: 63 %; average chamber concentration: 36 µg protein/l)
- No. of animals per dose:
- 4
Results and discussion
- Results:
- 3/4 animals induced with BSA-butyl isocyanate (conjugation: 63 %; average chamber concentration: 36 µg protein/l)
after 15 exposure days. The responses did not last long enough to challenge the test animals with other conjugates.
BSA-BI (bovine serum albumin-butyl isocyanate conjugate) induced only weak, transient responses to a few guinea pigs.
Applicant's summary and conclusion
- Executive summary:
Method: Guinea pigs were exposed by head only to an aerosol of protein-isocyanate conjugate.
Result: BSA-BI (bovine serum albumin-butyl isocyanate conjugate) induced only weak, transient
responses to a few guinea pigs.
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