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EC number: 258-964-5 | CAS number: 54079-53-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August 1978
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Justification for type of information:
- Data is from study report.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute toxicological investigations in female Wistar rats were conducted after oral administration of test chemical.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- [[4-[[2-(4-cyclohexylphenoxy)ethyl]ethylamino]-2-methylphenyl]methylene]malononitrile
- EC Number:
- 258-964-5
- EC Name:
- [[4-[[2-(4-cyclohexylphenoxy)ethyl]ethylamino]-2-methylphenyl]methylene]malononitrile
- Cas Number:
- 54079-53-7
- Molecular formula:
- C27H31N3O
- IUPAC Name:
- 2-[(4-{[2-(4-cyclohexylphenoxy)ethyl](ethyl)amino}-2-methylphenyl)methylidene]propanedinitrile
- Test material form:
- solid
- Details on test material:
- - Name of test material (as cited in study report): [[4-[[2-(4-cyclohexylphenoxy)ethyl]ethylamino]-2-methylphenyl]methylene]malononitrile
- Molecular formula: C27H31N3O
- Molecular weight: 413.562 g/mol
- Substance type: Organic
- Physical state: Solid
- Designation : MACROLEX Gelb 6G = Resolinbrilliantgelb 6
- Sponsor: FB division
- Date of Order: July 12, 1978
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- SPF-bred Wistar rats (strain Bor: WISW (SPF Cpb)
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann, Borchen, Germany
- Age at study initiation: about 14 weeks
- Weight at study initiation: initial weight was 150 to 200 g
- Identification: The anirnals were identified by marking their coat with picric acid.
- Housing: The rats were housed in groups of five animals each under conventional conditions in Makrolon Type-I11 cages on dust-free wood granules
- Diet (e.g. ad libitum): Feed (Altromin R 1324, producer: Altromin GmbH, Lage) was also available ad libitum.
- Water (e.g. ad libitum): tap water ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 1.5° C
- Humidity (%): about 60 ± 5 %.
- Photoperiod (hrs dark / hrs light): a 12-hour light/dark cycle (artificial light from 7 a.m. to 7 p.m. CET)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 5000 mg/kg
- Amount of vehicle (if gavage): 30 ml/kg
DOSAGE PREPARATION (if unusual): The substance was formulated in tap water at room temperature. - Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 10 female animals
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The animals were inspected several times on the day of administration, and twice daily during the following 14-day observation period (once on weekends and bank holidays). During inspections, the type, onset, duration, and intensity of clinical signs were recorded.
- Body weight: The animals were weighed individually at application and in groups at the end of the 14-day observation period.
- Necropsy of survivors performed: yes, the animals were sacrificed. - Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No animal died.
- Clinical signs:
- other: No female animal showed any signs of poisoning after Single administration of 5000 mg/kg.
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The acute oral toxicity dose (LD50) value was considered to be >5000 mg/kg bw, when 10 female SPF-bred Wistar rats were treated with the given test chemical via oral gavage route.
- Executive summary:
The acute oral toxicity study was conducted by using given test chemical in 10 female SPF-bred Wistar rats at the dose concentration of 5000 mg/kg bw.
The acute toxicity experiment was carried out with SPF-bred Wistar rats (strain Bor: WISW (SPF Cpb), bred by Winkelmann, Borchen, Germany). At the start of study the female rats were about 14 weeks of age; their initial weight was 150 to 200 g.
The substance was formulated in tap water at room temperature and once administered to 10 female animals at a constant application volurne of 30 ml/kg. The animals were inspected several times on the day of administration, and twice daily during the following 14-day observation period (once on weekends and bank holidays). During inspections, the type, onset, duration, and intensity of clinical signs were recorded. The animals were weighed individually at application and in groups at the end of the 14-day observation period. Subsequently the animals were sacrificed.
No animal died at 5000 mg/kg bw. No female animal showed any signs of poisoning after Single administration of 5000 mg/kg. Body weight development was not affected.
Under the condition of this study, the acute oral toxicity dose (LD50) value was considered to be >5000 mg/kg bw, when 10 female SPF-bred Wistar rats were treated with the given test chemical via oral gavage route.
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