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Ecotoxicological information

Toxicity to birds

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Description of key information

No data are available on the toxicity of trimellitic anhydride to birds.

Key value for chemical safety assessment

Additional information

In accordance with REACH Regulation 1907/2006, Annex X, Column 2, toxicity tests to birds do not need to be conducted as a large mammalian dataset is available (see toxicological studies). In addition, direct and exposure of the soil or water compartments is unlikely and the substance is not expected to be transferred indirectly to soil in significant quantities via disposal of STP sludges or aerial deposition. Primary exposure of terrestrial vertebrates, including birds, to the substance is therefore unlikely to occur. The substance has little potential to adsorb to soil and is not very persistent indicating that its bioconcentration potential may be considered to be negligible and, limited exposure notwithstanding, there is consequently no significant risk of secondary poisoning of birds via earthworms or fish.

Furthermore, there is no wide dispersive use as the chemical is only used in industrial processes. From industrial processes, the release of trimellitic anhydride into sewage is very limited, if not completely negligible, as the chemical is incorporated into a matrix during polymer manufacturing. In the unlikely case that trimellitic anhydride will reach sewage the anhydride group, which represents the single reactive and toxic functional moiety, rapidly hydrolyses to the respective di-acid. Overall, it is expected that trimellitic anhydride or its hydrolysis product trimellitic acid will not be present in sewage sludge, will not be distributed to sediment and, as a result, direct or indirect exposure of the aquatic and terrestrial compartments are unlikely.

Consequently studies of the toxicity of trimellitic anhydride to birds are considered to be unnecessary and unjustified on ethical grounds.