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EC number: 204-435-9 | CAS number: 120-92-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 26-NOV-1998 to 03-SEP-1999
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The test substance purity was known. The screening protocol was standard, but not validated for GLP by the quality assurrance unit.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- (only 3 animals were used per dose level)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Cyclopentanone
- EC Number:
- 204-435-9
- EC Name:
- Cyclopentanone
- Cas Number:
- 120-92-3
- Molecular formula:
- C5H8O
- IUPAC Name:
- cyclopentanone
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS:
- Species: COMMON SPECIES: rat
- Strain: RAT STRAINS: Sprague-Dawley
- Sex: male/female
- Source: Harlan Nossan S.r.l., Italy
- Age at study initiation: data not available
- Weight at study initiation: 251 to 274 g (males), 208 to 212 g (females)
- Fasting period before study, housing, diet, water, acclimation period: data not available
ENVIRONMENTAL CONDITIONS (temperature, humidity, air changes, photoperiod): data not available
In-life dates: data not available
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE: (area of exposure, % coverage, type of wrap if used): data not available
REMOVAL OF TEST SUBSTANCE: data not available
TEST MATERIAL: data not available - Duration of exposure:
- no data available
- Doses:
- 400 and 2000 mg/kg bw
- No. of animals per sex per dose:
- 3 females (400 mg/kg) and 3 males (2000 mg/kg)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: data not available
- Necropsy of survivors performed: yes - Statistics:
- not applicable
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: 95% CL not applicable
- Mortality:
- At the 400 and 2000 mg/kg bw doses, no mortality occurred
- Clinical signs:
- other: At the lower dose (400 mg/kg), no clinical signs were observed. At the highest dose (2000 mg/kg), piloerection and staining of skin/fur were observed during period of exposure and disappeared within 24 hours (See table 1 in the attached document).
- Gross pathology:
- necropsy after 14 days revealed no abnormalities at the 2 doses.
Any other information on results incl. tables
CYCLOPENTANONE: dermal LD50 (Nunziata A, 1999)
Table 1: Clinical signs and mortality
Dose level |
Clinical signs |
Mortality |
(mg/kg) |
||
2000 |
Piloerection and staining of skin/fur during period of exposure. Recovery within 24 hours. Necropsy after 14 days revealed no abnormalities. |
0/3 |
400 |
No clinical signs observed. Necropsy after 14 days revealed no abnormalities. |
0/3 |
Table 2: body weight changes
Dose level |
Animal |
Body weight (g) on Day: |
Change in body weight |
|
(mg/kg) |
Number |
1 |
15 |
Day 1-15 |
112 |
274 |
339 |
65 |
|
2000 |
114 |
269 |
343 |
74 |
116 |
251 |
320 |
69 |
|
111 |
209 |
221 |
12 |
|
400 |
113 |
208 |
227 |
19 |
115 |
212 |
255 |
43 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- At the 2 tested doses (400 and 2000 mg/kg) no mortality were observed in male and female rats after dermal exposure.
- Executive summary:
In an acute dermal toxicity study (Nunziata A, 1999), groups of Sprague-Dawley male and female rats (3/group) were dermally exposed to cyclopentanone (99.8% purity) undiluted at doses of 400 and 2000 mg/kg bw. Animals then were observed for 14 days.
Dermal LD50 for male and female rats was greater than 2000 mg/kg bw. Based on this result, cyclopentanone is not classified for dermal acute toxicity.
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