Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 218-915-0 | CAS number: 2280-49-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study according to GLP
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- mouse local lymph node assay (LLNA)
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- female
- Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- Test item: 0 % (vehicle control), 2 %, 10 % and 50 %.
Positive control: 40 % Alpha Hexyl Cinnamic Aldehyde - No. of animals per dose:
- The modified Local Lymph Node Assay (IMDS) was performed on 24 female NMRI mice of the strain HsdWin:NMRI (6 animals/test item group and 6 control animals) to determine if there is any specific (sensitizing) or non-specific (irritant) stimulating potential of the test item N-Phenyl-N-[(trichloromethyl)thio ]benzenesulphonamide. A concurrent control of 6 animals treated with Alpha Hexyl Cinnamic Aldehyde was included.
- Parameter:
- SI
- Remarks on result:
- other: Not applicable because the modified Local Lymph Node Assay (IMDS) was performed.
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: Not applicable because the modified Local Lymph Node Assay (IMDS) was performed.
- Interpretation of results:
- Category 1A (indication of significant skin sensitising potential) based on GHS criteria
- Executive summary:
In conclusion, these results show that the test item N-Phenyl-N[( trichloromethyl)thio]benzenesulphonamide has a strong sensitizing potential in mice after dermal application of a 2 % concentration. Although it is not possible to calculate an exact EC value from the data obtained, it is clear that the EC value is in any case below 1%.
Reference
Compared to vehicle treated animals there were clear increases in weights of the draining lymph nodes and in the cell counts at all dose groups. These changes are of statistical significance. The "positive level" of index 1.4 [6, 8, 9] was exceeded for the cell counts in all
dose groups.
The "positive level" of ear swelling which is 2x 10·2 mm increase [8, 9], i.e. about 10% of the control values, has been exceeded in all dose groups (Appendix 11.2.2.). These changes are of statistical significance. A significant increase compared to vehicle treated animals regarding ear weights was detected in all dose groups as well. An increase in these parameters would point to an acute irritating (inflammatory) response. However, such an irritant property could also be combined with a strong skin sensitizing
potential of a test compound.
In conclusion, these results show that the test item N-Phenyl-N[( trichloromethyl)thio]benzenesulphonamide has a strong sensitizing potential in mice after dermal application of a 2 % concentration. Although it is not possible to calculate an exact EC value from the data obtained, it is clear that the EC value is in any case below 1%.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
In conclusion, these results show that the test item N-Phenyl-N[( trichloromethyl)thio]benzenesulphonamide has a strong sensitizing potential in mice after dermal application of a 2 % concentration. Although it is not possible to calculate an exact EC value from the data obtained, it is clear that the EC value is in any case below 1%.
Justification for selection of skin sensitisation endpoint:
Guideline study according to GLP
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on the LLNA study the compound will be labelled Skin Sens 1A according to GHS.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.