Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-328-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral LD50 male rats = 30.1 ml/kg (26.8 g/kg) = 26800 mg/kg.bw expert judgement: Not subject to classification according to GHS);
LD50(dermal, rat, 24h) > 2000 mg/kg.bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 26 800 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- well performed, according to OECD guideline 402
Additional information
All present studies for C12 -14 Alkyl Glycidyl Ether are used for read-across to avoid duplicate tests due to limited available information of C13 -15 Alkyl Glycidyl Ether.
Acute toxicity: oral
Based on the results (Dr. U. Hackenberg, 1974), it is deduced that oral LD50 male rats = 30.1 ml/kg (26800 mg/kg.bw.). In this study, four groups each of 10 male rats and one group of 20 male rats were treated with the undiluted substance. The application volume was 17.8 mL/kg, 23.7 mL/kg, 27.4 mL/kg and 31.6 mL/kg, respectively.
Mortality and clinical signs were observed during 14 days after treatment. No deaths occurred in the control group and test groups treated with 17.8 mL/kg, 23.7 mL/kg and 27.4 mL/kg. 16 out of 20 rats died in the highest treated group (31.6 mL/kg) during the course of the study.
Loss of body weight was noted in the 31.6 mL/kg treated group during the first week of observation, but the surviving animals did not recover completely at the end of the observation period compared with the control animals.
For the 31.6 mL/kg treated animals, red discoloration of the stomach with hemmorhage was noted at the unscheduled necropsy in 12 out of 16 animals. Blood in the stomach was observed in 5 animals. Red discoloration of the small intestine with hemmorhage was observed in 10 animals and blood in the small intestine was seen in 12 animals.
Acute toxicity: inhalation
As the test material is a liquid with high boiling point (> 300 degree C) and low vapour pressure (< 1 Pa at 25 degree C), it is reasonable to expect that the inhalation route will not be a significant exposure route to the test material. Thus, there is no additional test requirement for this endpoint.
Acute toxicity: dermal
A GLP dermal test (J. R. Jones, 1990) following OECD guideline 402 showed that no signs of toxicity were observed following a single, 24 hours, occluded application of the test material to intact Sprague-Dawley strain rats’ skin for 24 hrs, at a dose level of 2000 mg/kg bodyweight. The acute dermal median lethal dose (LD50) of the test material in the Sprague-Dawley strain rat was found to be greater than 2000 mg/kg.bw.
Justification for selection of acute toxicity – oral endpoint
Only one study is available.
Justification for selection of acute toxicity – inhalation endpoint
As the test material is a liquid with high boiling point (> 300
degree C) and low vapour pressure (< 1 Pa at 25 degree C), it is
reasonable to expect that the inhalation route will not be an
significant exposure route to the test material. Thus, there is no
additional test requirement for this endpoint.
Justification for selection of acute toxicity – dermal endpoint
guideline test with GLP
Justification for classification or non-classification
Based on the results of present studies (LD50(oral, male rat) = 26800 mg/kg.bw; LD50(dermal, rat, 24h) > 2000 mg/kg.bw), it can be concluded that test substance shall not be classified under the CLP (Regulation EC No. 1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.