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EC number: 701-116-0 | CAS number: 2156592-45-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- GLP compliance:
- yes (incl. QA statement)
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Buffers:
- - pH: 4, 7 and 9
Demineralized water (Milli-Q system); methanol (Sigma Al drich); trifluoroacetic acid, TFA (Sigma Aldrich); buffer pH 7.00 (Bernd Kraft; phosphate mixture); buffer pH 9.00 (Bernd Kraft; boric acid, potassium chloride, sodium hydroxide); buffer pH = 4.008 (Fluka); buffer pH = 9.180 (Fluka) for testing of pH me ter. - Preliminary study:
- A preliminary test had shown that even with the addition of 1 % of acetonitrile as solubilizer the solubility of the test item in buffer pH 4 is insufficient.
100.68 mg and 114.25 mg ofthetest item, exactlyweighed, were each dissolved in and filled up to 100 ml with buffer 7 or 9 and gassed with nitrogen.
The test item is not completely soluble in the buffer solution pH 7. Therefore this mixture was stirred for 2 h and then fil tered using 0.1 µm membrane filters (Acrodisk 32/0.1 µm). These solutions were applied for the tests.
Vials containing each about 1.5 ml of test solution were stored at the 50°C.
After defined time intervals aliquots of the test solutions were injected into the HPLC system. - Test performance:
- The test item was insoluble at pH values of 4 and pH7.
- Transformation products:
- no
- Details on hydrolysis and appearance of transformation product(s):
- A GLP compliant study on the hydrolysing potential of the test substance has been conducted according to OECD guideline 111 [BASF SE 2013]. The hydrolysis of the test item at pH4 and pH7 cannot be determined because the solubility of the test item is too low. At pH9 (50°C) no hydrolysis could be observed within 5 days.
- Key result
- pH:
- 9
- Temp.:
- 50 °C
- DT50:
- >= 1 yr
- Type:
- not specified
- Remarks on result:
- hydrolytically stable based on preliminary test
- Remarks:
- At pH 9, 50°C: no hydrolysis could be observed within 5 days.
- Remarks on result:
- other: The hydrolysis of the test item at pH4 and pH7 cannot be determined because the solubility of the test item is too low. At pH9 (50°C) no hydrolysis could be observed within 5 days.
- Details on results:
- A GLP compliant study on the hydrolysing potential of the test substance has been conducted according to OECD guideline 111 [BASF SE 2013]. The hydrolysis of the test item at pH4 and pH7 cannot be determined because the solubility of the test item is too low. At pH9 (50°C) no hydrolysis could be observed within 5 days.
- Conclusions:
- No hydrolysis occured at pH 9. For pH 4 and pH 7 no results can be obtained because the substance is insoluble in water. Even by using a solubilizer (1% acetonitrile) the solubility could not be improved.
Reference
The hydrolysis of the test item at pH4 and pH7 cannot be determined because the solubility of the test item is too low.
At pH9, 50°C: no hydrolysis could be observed within 5 days.
Description of key information
In accordance with Regulation 1907/2006 (EC) Annex XI general rules for adaption of the standard testing regime set out in Annexes VII to X, section 2, testing may be omitted. Due to the properties of the test substance, testing is technically not possible. Therefore, an experimentally determined t0.5 value for pH4 and pH7 cannot be provided.
At pH 9, 50 °C: no hydrolysis could be observed within 5 days. Resulting in T0.5 > 1 year.
The hydrolysis of the test item at pH 4 and pH 7 cannot be de termined because the solubility of the test item is too low. Even with the addition of 1% acetonitrile as solubilizer the solubility of the test tiem is insufficient.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 50 °C
Additional information
A GLP compliant study on the hydrolysing potential of the test substance has been conducted according to OECD guideline 111 [BASF SE 2013]. However, the hydrolysis of the test item at pH4 and pH7 cannot be determined because the solubility of the test item is too low. At pH9 (50°C) no hydrolysis could be observed within 5 days.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.