Registration Dossier
Registration Dossier
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EC number: 801-093-8 | CAS number: 1315251-11-6
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Body burden: For long-term fish toxicity the NOEC is derived using the Lethal and Critical Body burden approach as described in the ECHA R.7b Guidance Appendix 7.8-3 (2017) using the structure, molecular weight, short-term toxicity to fish and the aquatic bioconcentration factor (BCF) as input data. The substance is identified as a neutral organic substance in ECOSAR 2.0 and is assumed to follow anon-polar (Type I) narcotic mode of action (acute = 1 to 10 mmol/kg, chronic = 0.1 to 1 mmol/kg; Thompson and Stewart 2003).
The Lethal Body Burden (LBB) approach for the substance is calculated first to see which mMol/kg is applicable for the CBB approach. The used equation for long-term fish toxicity is CBB mMol/kg fish = NOEC mMol/L x BCF. The CBB is estimated to between 0.1 and 1 mMol/kg fish. The LBB (LBB mMol/kg fish = LC50 mMol/L x BCF) calculation for the substance results in 1.166 mMol/kg fish (using LC50 of 0.55 mg/L, BCF of 513 L/kg and a molecular weight of 242). This LBB value shows that for the CBB approach the 0.117 mMol/kg fish can be used (instead of 0.1 or 1 mMol/kg fish). The long-term fish NOEC thus becomes 0.055 mg/L (0.117 mMol/kg = NOEC mMol/L x 513 (molecular weight 242).
Uncertainty of the predictions in LBB/CBB approach: The LBB and CBB approaches are most applicable to narcotic type of chemicals. As described above, based on the structure, the substance is a neutral organic substance with a narcotic mode of action (baseline toxicity). Thus it is not assumed to have a specific mode of action. Furthermore, even though the short--term toxicity to fish and aquatic bioaccumulation studies have been performed with different fish species, the BCF used here is normalised to 5% lipid content which should diminish any further uncertainty. In view of the reasoning above, the uncertainty of the CBB prediction is limited. The long-term fish toxicity of substance derived is considered reliable.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- NOEC
- Effect concentration:
- 0.055 mg/L
Additional information
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