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Diss Factsheets
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EC number: 939-201-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Biodegradation screening studies for suitable read across substances indicate that Reaction mass of sodium hydrogen N-(1-oxooctadecyl)-L-glutamate and stearic acid is readily biodegradable according to OECD criteria (> 94% biodegradation in 28 and 21 days, respectively). Due to their ready biodegradability, hydrolysis is not expected to be a relevant degradation pathway for this substance. This assumption is based on the assumption that i) indirect photo transformation is negligible since the substance will not evaporate into the atmosphere based on its very low volatilization potential (vapour pressure < 0.00001 Pa) and ii) hydrolysis is negligible since most amides hydrolyze to acids extremely slowly under environmental conditions with half-lives measured in centuries. Electronegative groups on carbon or nitrogen greatly accelerate base catalyzed hydrolysis, but alkyl groups on nitrogen retard both acid and base catalyzed processes (Mabey and Mill, 1978).
Reaction mass of sodium hydrogen N-(1-oxooctadecyl)-L-glutamate and stearic acid is high water soluble (4.36 g/L) and has a low log Kow value (log Kow < -1.85) assuming a low adsorption potential. Thus, the substance will tend to be mainly distributed into the water phase if entering the environment. However, as the substance is considered to be readily biodegradable, persistence in this compartment is not expected.
Bioaccumulation in aquatic organisms is unlikely since Reaction mass of sodium hydrogen N-(1-oxooctadecyl)-L-glutamate and stearic acid has a very low log Kow of -1.85, which assume that the substance will not cross biological membranes. This assumption is supported by the complex structure and conformational flexibility of the substance, which indicate that passive diffusion through biological membranes is also sterically hindered.
In addition, if uptake by fish species occurs, extensive and fast biotransformation of the substance by amide hydrolases into glutamic acid and fatty acids is expected. Both glutamic acid and fatty acids will then be further used by these organisms as their main source of energy throughout all the different life stages (e.g., Juerss and Bastrop, 1995).
Juerss K, Bastrop R. 1995. Chapter 7: Amino acid metabolism in fish. Biochem Mol Biol Fish 4: 159 -189
Mabey W & Mill T. 1978. Critical review of hydrolysis of organic compounds in water under environmental conditions.J Phys Chem Ref Data 7(2): 383-415
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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