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Diss Factsheets
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EC number: 700-792-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil macroorganisms except arthropods
Administrative data
- Endpoint:
- toxicity to soil macroorganisms except arthropods: short-term
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 21 June 2012 - 05 July 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study carried out to international guidelines and to GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 207 (Earthworm, Acute Toxicity Tests)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.8 (Toxicity for Earthworms: Artificial Soil Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Reaction mass of 1,2,2,6,6-pentamethylpiperidin-4-yl hexadecanoate and 1,2,2,6,6-pentamethylpiperidin-4-yl octadecanoate
- EC Number:
- 700-792-4
- Molecular formula:
- C26H51NO2, C28H55NO2
- IUPAC Name:
- Reaction mass of 1,2,2,6,6-pentamethylpiperidin-4-yl hexadecanoate and 1,2,2,6,6-pentamethylpiperidin-4-yl octadecanoate
- Details on test material:
- - Name of test material (as cited in study report): T-1640L
- Substance type:
- Physical state: fawn coloured wax
- Analytical purity: 98.7%
- Purity test date: 20 May 2011
- Lot/batch No.: 10121
- Expiration date of the lot/batch: 12 Aoril 2013
- Stability under test conditions: stable
- Storage condition of test material: refrigerated in the dark, desiccated
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test substrate
- Vehicle:
- no
- Details on preparation and application of test substrate:
- - Method of mixing into soil (if used): electric hand held mixer
- Controls: water, Chloroacetamide
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): none
Test organisms
- Test organisms (species):
- Eisenia fetida
- Animal group:
- annelids
- Details on test organisms:
- TEST ORGANISM
- Common name: Eisenia fetida
- Source: In-house culture at Huntingdon Research Centre
- Age at test initiation (mean and range, SD): no data
- Weight at test initiation (mean and range, SD): 300 - 600 mg
ACCLIMATION
- Acclimation period: no
- Acclimation conditions (same as test or not):
- Health during acclimation (any mortality observed):
Study design
- Study type:
- laboratory study
- Substrate type:
- artificial soil
- Limit test:
- no
- Total exposure duration:
- 14 d
Test conditions
- Test temperature:
- 19.8 - 20.6 °C
- Moisture:
- 35%
- Details on test conditions:
- TEST SYSTEM
- Test container (material, size): 1 litre, glass
- Amount of soil or substrate: 2200 g divided
- No. of organisms per container (treatment): 10
- No. of replicates per treatment group: 4
- No. of replicates per control: 4
SOURCE AND PROPERTIES OF SUBSTRATE (if soil)
- Composition (if artificial substrate): 70% quartz sand, 20% kaolin clay, 10% sphagnum peat
- Organic carbon (%):
- Maximum water holding capacity (in % dry weight):
- CEC:
- Pretreatment of soil: pH adjusted to 6.0 ± 0.5 with calcium carbonate
OTHER TEST CONDITIONS
- Photoperiod: no data
- Light intensity: between 520 and 796 lux
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
Daily observations for behavioural and pathological signs
Mortality on days 7 and 14
Bodyweights prior to treatment and on day 14
VEHICLE CONTROL PERFORMED: no, no vehicle
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 1.8 - Nominal and measured concentrations:
- Nominal concentrations: 95.3, 171.5, 308.6, 555.6, 1000 mg active ingredient/kg
- Reference substance (positive control):
- yes
- Remarks:
- chloroacetamide
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 7 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality
- Duration:
- 14 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality
- Details on results:
- - Mortality at end of exposure period: 0 in any group
- Total mass of adults at beginning of test:
- Changes in body weight of live adults (% of initial weight) at end of exposure period:
Control +8.3
95.3 T-1640L +10.2
171.5 T-1640L +5.0
308.6 T-1640L +2.0
555.6 T-1640L -0.5
1000 T-1640L -1.5
- No. of offspring produced: no data
- No. of unhatched cocoons: no data
- Morphological abnormalities: none
- Behavioural abnormalities: none - Results with reference substance (positive control):
- - Results with reference substance valid? yes
- Relevant effect levels: mortality, 39 of 40 worms died - Reported statistics and error estimates:
- Bodyweights were compared using Analysis of variance, followed by a two-tailed Williams’ test (1971, 1972).
The decrease in bodyweight at 1000 mg a.i./kg was statistically significant - (p <0.05) - in comparison to the increase in the control.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- At seven and 14 days after treatment there was no mortality in any of the T-1640L treatment groups.
The 7 and 14-day LC50 values were estimated to be >1000 mg a.i./kg dry soil.
The No Observed Effect Concentration was 1000 mg a.i.kg/dry soil.
There was a significant treatment related difference in bodyweight between the treatment and control group at 1000 mg a.i./kg dry soil only
(p <0.05).
The study was considered valid because less than 10% mortality was observed in the water control group.
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