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Diss Factsheets
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EC number: 700-485-5 | CAS number: 939402-02-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 10
- Absorption rate - dermal (%):
- 10
- Absorption rate - inhalation (%):
- 10
Additional information
Inhalation
No specific studies on inhalation of the substance itself are available. As the substance is known to be minimally absorbed from the ADME studies, and given that the vapour pressure of DVS005u is not sufficiently volatile to indicate that this is a route of exposure, as a worst case, 10% inhalation absorption default is assigned.
Dermal
Chapter R.7c: Endpoint specific guidance details as follows:
Substances that can potentially be taken up across the skin include gases and vapours, liquids and particulates. A tiered approach for the estimation of skin absorption has been proposed within a risk assessment framework (EC, 2007): Initially, basic physico-chemical information should be taken into account, i.e. molecular mass and lipophilicity (log P). Following, a default value of 100% skin absorption is generally used unless molecular mass is above 500 and log P is outside the range [-1, 4], in which case a value of 10% skin absorption is chosen (de Heer et al., 1999).
The substance has the following parameters:
MW range of 520 - 731;
Water solubility: < 0.1 mg/l
Log Kow: 6.58 ± 0.32.
Taking account of the details within Table R.7.12—3 Interpretation of data regarding dermal absorption, a dermal absorption of 10% is proposed, based on the guidance. This is reinforced by the fact that the oral absorption rate is approximately 10% and is considered appropriate.
Oral
Oral absorption of DVS005 (Weston 705T) was found to be low (range 4.01 to 7.75%) although this was higher after repeated administration compared with a single dose. Of this, urinary excretion represented the major component (range 3 to 6%). Altogether 9 metabolites, all below 5% of the administered dose, were found in the urine.
Faecal elimination accounted for 81 to 92% on the radioactivity in both males and females after 48 hours, for respectively the low and high dose group. In the repeated dose group (100 mg/kg) the faecal elimination was slightly lower compared with the single dose groups. Since no metabolites were found in the faeces it was considered that this material represented unabsorbed material.
At termination of the study, the average total remaining radioactivity in blood, carcass plus tissues was between 0.397 and 0.844% of the administered dose after oral dosing. The mean percentage of radioactivity in the carcass was 0.122-0.157%.
As a worst case, an oral absorption of 10% is proposed.
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