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Diss Factsheets
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EC number: 700-155-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Dose descriptor:
- NOAEL
- 300 mg/kg bw/day
Additional information
In a combined repeated toxicity and screening reproductive toxicity study (OECD 422, GLP) peroxidised corn oil (in olive oil as vehicle) was administered to 12 Wistar rats/sex/dose in by gavage at dose levels of 0 (olive oil), 100, 300 and 1000 mg/kg bw.
Females were treated 14 days before mating, 14 days during mating, 22-24 days during gestation and 4 days during lactation. Males were treated 56 days.
There were no test article-related deaths of animals during the study. All animals lived through observation period without important visible signs of intoxication. The test article was very well tolerated by animals of all dose groups and no sign of systemic toxicity was observed.
No differences in the length of gestation were registered. Decrease of pup’s number in the litter, litter’s body weight, corpora lutea and implantation sites in females of dose group 1000 mg/kg against control group were recorded.
No effects were observed in offsprings up to 1000 mg/kg bw.
Based on the reproduction toxicity, the no observed adverse effect level for female fertility was concluded to be 300 mg.kg-1.
The no observed adverse effect level for male fertility was concluded to be 1000 mg/kg.
The NOAEL for systemic toxicity in males and females was concluded to be 1000 mg/kg bw.
This combined repeated toxicity and screening reproductive toxicity study in the rats is acceptable and satisfies the guideline requirement for a Reproduction screening Toxicity Study (OECD 422) in rats.
Short description of key information:
NOAEL (parental, male) = 1000 mg/kg bw/d
NOAEL (parental, female) = 300 mg/kg bw/d
(OECD 422, rat, oral, GLP)
Effects on developmental toxicity
Description of key information
NOAEL (offspring, screening, external abnormalies) = 1000 mg/kg bw/d
(OECD 422, rat, oral, GLP)
Additional information
See effect on fertility.
Justification for classification or non-classification
Based on the classification criteria of Annex VI Directive 67/548/EEC or UN/EU GHS, and given the NOAEL at 300 mg/kg bw in females and the NOAEL at 1000 mg/kg bw in males (OECD 422, rat, gavage, GLP), no classification for reproductive and developmental toxicity is warranted according to the criteria of Annex VI Directive 67/548/EEC or UN/EU GHS.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.