Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 931-210-9 | CAS number: 1266534-73-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
skin:
not irritating (RA Zeolite cuboidal)
eye:
not irritating (RA Zeolite cuboidal)
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritation:
No data for skin irritation are available for the target substance Aluminium silicate and titanium oxide matrix doted with vanadium, nickel, and antimony. Therefore, data from the analogue approach source substance Zeolite cuboidal were applied to cover the endpoint skin irritation in-vivo for the target substance:
Intact and abraded rabbit skin was exposed for 24 hours to a Zeolite, cuboidal, crystalline, synthetic, non-fibrous, whose surface was modified with 10% rare earth elements under occlusive conditions according to the guidelines of the Federal Hazardous Substance Labelling Act. Neither erythema nor edema was observed in any rabbit after 24 and 48 hours, respectively (Grace, 1976, RL2).
Eye irritation:
An in-vitro HET-CAM test was conducted with the target substance, according to the OECD draft test guideline 405 (dated 24 April 2002). Hen´s eggs with an age of nine days were used. The test material was brought onto the surface of the CAM of an egg which had been incubated at 38.5 °C and 58 % humidity for nine days. Observation time was five minutes at room temperature. Physiological sodium chloride solution was used as negative control. The negative control showed no irritating effects on the blood vessels under the membrane. Solutions of SDS (1 %) and NaOH (0.1 N) were used as positive controls. The positive controls induced a severe irritation on the blood vessels. The test material showed no effects on the blood vessels of the CAM. The calculated mean irritation score is 0.0. In conclusion, it can be stated that under the experimental condition chosen, the test material possesses no irritation potential (Paulus 2009, RL1).
Additionally, in-vivo data for skin irritation are provided from the analogue approach source substance Zeolite cuboidal, which support the results obtained from the in-vitro data:
Zeolite, cuboidal, crystalline, synthetic, non-fibrous, whose surface was modified with approximately 10 % rare earth elements at a dose of 100 mg induced slight redness of the conjunctivae in 2 out of 6 rabbits. This slight redness in one animal lasted until observation day 3. The reversibility of these effect was not observed further since the observation period had ended at the time. As well as the other surface modified zeolites, the test substance was not considered to be ocular irritating under the conditions of the test (Grace, 1976, RL2).
Respiratory irritation:
No data are available.
Additional data for irritation are available for the following source substances which serve as potential data sources for the analogue approach of Aluminium silicate and titanium oxide matrix doted with vanadium, nickel, and antimony:
- Source chemical 1 - Fluidized catalytic cracking (FCC) catalysts:
Skin: not irritating (S); Calkins and Ward 1976
Eye: not irritating (S); Calkins and Ward 1976
- Source chemical 2 - Zeolite, cuboidal, crystalline, synthetic, non-fibrous:
Skin: not irritating (S); WR Grace 1976; de Jouffrey 1996
Eye: not irritating (K); de Jouffrey 1996
- Source chemical 3 - Kaolin, calcined:
Skin: not irritating (K); Wnorowski 1997
- Source chemical 4 - Silicic acid, aluminium salt:
Skin: not corrosive in-vitro (Epi Derm) (K); Paulus 2010
Eye: corrosive in-vitro (HET-CAM) (K); Paulus 2010
- Source chemical 5 - Aluminium oxide:
Skin: not irritating (K); Degussa 1979
Eye: not irritating (K); Degussa 1979
- Source chemical 6: Kaolin:
Eye: not irritating (K); Merkel 1997
In accordance with the target substance, the available data for the source substances also provide negative results for skin and eye irritation, except for source chemical 4 (Silicic acid, aluminium salt): In a HET CAM test, Silicic acid, aluminium salt was corrosive in-vitro. This result however is considered not relevant for the target substance Aluminium silicate and titanium oxide matrix doted with vanadium, nickel, and antimony, as an additional HET CAM test provided negative results.
The respective references for the source substance data can be found in the data matrix of the justification for the analogue approach, which can be found either in the CSR or as attachment in Iuclid section 13.
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
Based on the results obtained, Aluminium silicate and titanium oxide matrix doted with vanadium, nickel, and antimony does not fulfill the criteria to be classified for skin-, and eye irritation according to DSD (67/548/EEC) or CLP (1272/2008/EC).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.