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EC number: 700-457-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
The main components of LIMUS Sambaydestillation are N-(n-butyl) triphosphoric triamide (NBPT) and N-(n-propyl) triphosphoric triamide (NPPT).
The Australian Government has assessed NBPT in the Existing Chemical Secondary Notification Assessment Report NA/467S (February 2011) and also provided information on toxicokinetics, metabolism and distribution:
Absorption of NBPT via oral route was almost complete, as 74.39% of the given dose was considered to be absorbed. Four out of 8 rats had blood sample collected through a jugular cannula at various times after dosing (between 1 to 120 hours). Times at which peak concentrations were reached in the blood stream (tmax) in three of the four rats were within one hour of administration with a mean peak concentration (Cmax) of 80.18 μg-equi/g. No data were available on dermal or inhalation absorptions.
NBPT was distributed to most of the organs based on the data at termination. Samples from liver, mesenteric fat, kidney, carcass and spleen combined registered higher NBPT concentrations than that in blood samples. Although lung samples were not measured in the experiment, NBPT is believed to be distributed to the lungs before its elimination into air. Regarding the quantitative distributions in different organs, higher amounts of NBPT were seen in the carcass, liver and blood with minor amounts in the kidney, spleen and mesenteric fat. After 7 days, 2.92% of the given dose remained in the body. NBPT concentrations in blood samples followed a biphasic declination pattern, decreasing rapidly to less than 14% of the Cmax 24 hours after dosing and then to <5% by 168 hours. There were no data on protein binding or enterohepatic circulation of NBPT.
Two major metabolites of NBPT were separated and identified from the urine samples. One was the glucuronic acid conjugate of NBPT, the structure of which was confirmed by LC/MS. Another was confirmed to be N-(n-butyl)-thiophosphoric diamide by both LC/MS and NMR. No metabolic pathways had been investigated on the formation of CO2 which was excreted via lungs.
Elimination of NBPT from the blood stream showed a linear declination with a calculated t½ of 78 hours. After a single oral dose, 80.12% NBPT was excreted in 7 days. NBPT was mainly eliminated via expired air (as CO2), urine and faeces with averages of 35.4%, 24.4% and 8.7% of the administered dose, respectively. Some residues were recovered from cage rinses (11.7%).
Based on structural similarities between NBPT and NPPT (NPPT is one CH2 -group shorter) significant differences between NBPT and NPPT concerning toxicokinetics, metabolism and distribution are not expected.
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