Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 904-797-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018-03-07 - 2017-07-10
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- The department of health of the government of the united kingdom
- Type of method:
- flask method
- Specific details on test material used for the study:
- Identification: m- & o-terphenyl rxn mass
Appearance/Physical state: a cream colored solid block
Storage conditions: approximately 4 °C, in the dark, under nitrogen - Key result
- Water solubility:
- <= 0 g/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 7
- Details on results:
- see "Any other information on results inc. tables"
- Conclusions:
- The water solubility of the test item has been determined to be less than 1.0 x 10E-4 g/L of solution at 20.0 ± 0.5 °C.
- Executive summary:
The water solubility determination was carried out by a flask method according to GLP, using a procedure designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995. The water solubility of the test item has been determined to be less than 1.0 x 10-4 g/L of solution at 20.0 ± 0.5 °C.
Reference
Preliminary Test
The preliminary estimate of the water solubility at 20.0 ± 0.5 °C was less than 1.0 x 10-4 g/L. The solution had a pH of 6.2.
Definitive Test
The mean total peak areas relating to the standard and sample solutions are shown in the following table:
Solution | Mean Total Peak Area |
Standard 2.11 mg/L | 2.8128 x 105 |
Standard 2.03 mg/L | 2.7045 x 105 |
Standard solution matrix blank | none detected |
Sample solution matrix blank | none detected |
Sample 1A | 3.3639 x 104 |
Sample 1B | 3.9213 x 104 |
Sample 2A | 2.6201 x 104 |
Sample 2B | 2.8023 x 104 |
Sample 3A | 4.0894 x 104 |
Sample 3B | 3.1571 x 104 |
The concentration (g/L) of test item in the sample solutions is shown in the following table:
Sample Number | Time Shaken at 30 ºC (hours) |
Concentration (g/L) |
Solution pH |
1 |
24 |
<1.0 x 10-4 |
6.8 |
2 |
48 |
<1.0 x 10 -4 |
6.9 |
4 |
72 |
<1.0 x 10-4 |
7.0 |
Overall result: <1.0 x 10-4 g/L at 20.0 ± 0.5 ºC
Validation
The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 0.2 to 5.0 mg/L. The results were satisfactory with a first order correlation coefficient (r) of 0.9999 being obtained.
Assessment of the sample extraction procedure was performed and proved adequate for the test. At a nominal fortification concentration of 0.1 mg/L, a mean percentage recovery of 98.9% was obtained (n = 5, range 97.9 to 99.6%).
Test sample concentrations have not been corrected for the recovery of analysis.
Discussion
On completion of the re-equilibration period, the samples were clear and colorless solutions with excess, undissolved test item remaining visibly present. After centrifugation, the
supernatants were isolated for analysis. Each supernatant was visually observed to be clear, colorless and free from un-dissolved test item prior to extraction.
On analysis of the sample solutions, a limited response was observed at the retention time of the first of the two dominant components; however, no response was observed for the second component. In addition, the response obtained for the first component remained below the validated limit of quantification generated from the procedural recoveries. Therefore a limit value has been reported for the overall water solubility result.
Conclusion
The water solubility of the test item has been determined to be less than 1.0 x 10-4 g/L of solution at 20.0 ± 0.5 °C.
Description of key information
The water solubility determination was carried out by a flask method according to GLP, using a procedure designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995. The water solubility of the test item has been determined to be less than 1.0 x 10-4g/L of solution at 20.0 ± 0.5 °C.
Key value for chemical safety assessment
- Water solubility:
- 0 g/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test item has been determined to be less than 1.0 x 10-4 g/L of solution at 20.0 ± 0.5 °C. Therefore for chemical safety assessment this limit-value was chosen.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.