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EC number: 611-390-2 | CAS number: 56467-43-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Under the conditions of the present study, single oral application of the test item 4-(Methacryloyloxy)benzophenone to rats at a dose of 2000 mg/kg body weight was associated with slight to severe signs of toxicity but no mortality.
The median lethal dose of 4-(Methacryloyloxy)benzophenone after a single oral administration to female rats, observed over a period of 14 days is: LD50 cut off (rat): 5000 mg/kg body weight.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 05.11.2009 to 05.01.2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
- Specific details on test material used for the study:
- 4-(Methacryloyloxy) bezophenone 97.26 %
Benzophenone acetate: 1.95 % - Species:
- rat
- Strain:
- Wistar
- Remarks:
- Healthy rats, WISTAR rats Crl: WI(Han) (Full-Barrier)
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Test System
Species/strain: Healthy rats, WIST AR rats Crl: WI(Han) (Full-Barrier)
Source: Charles River, 97633 Sulzfeld, Germany
Sex: female, non-pregnant, nulliparous
Number of animals: 3 per step
Age at the beginning of the study: 8 - 9 weeks old
Body weight at the beginning of the study:
Animals no. 1- 3, step 1: 158-164 g;
Animals no. 4- 6, step 2: 163 - 170 g;
The animals were derived from a controlled full barrier maintained breeding system (SPF). According to Art. 9.2, No.7 of the German Act on Animal Welfare the animals were bred for experimental purposes.
Housing and Feeding Conditions
Full-barrier in an air-conditioned room Temperature: 22 ± 3 °C
Relative humidity: 55 ± 10%
Artificial light, sequence being 12 hours light, 12 hours dark
Air change: 10 x I hour
Free access to Altromin 1324 maintenance diet for rats and mice (lot no. 1452)
Free access to tap water, sulphur acidified to a pH value of approx. 2.8 ( drinking water, municipal residue control, microbiological control at regular intervals)
The animals were kept in groups in IVC cages, type III H, polysulphone cages on Altromin saw fibre bedding (lot no. 06.06.09)
Certificates of food, water and bedding are filed at BSL BIOSERVICE Adequate acclimatisation period ( at least five days, for details see Schedule) - Route of administration:
- oral: gavage
- Vehicle:
- cotton seed oil
- Remarks:
- (Sigma, lot no. 038K0009, expiry date: 01.04.2010)
- Details on oral exposure:
- The test item was administered at a single dose by gavage using a feeding tube.
The test item was administered at a dose volume of 10 mL/kg body weight. - Doses:
- 2000 mg/kg body weight
- No. of animals per sex per dose:
- 3 per step
- Control animals:
- no
- Details on study design:
- The starting dose was selected to be 2000 mg/kg body weight. No compound related mortality was recorded for any animal of step I or 2. Based on these results and according to the acute toxic class method regime no further testing was
required.
Weight Assessment:
All animals were observed for 14 days after dosing for general clinical signs, morbidity and mortality.
Clinical Examination:
A careful clinical examination was made several times on the day of dosing (at least once during the first 30 minutes and with special attention given during the first 4 hours post-dose). As soon as symptoms were noticed they were recorded.
Thereafter, the animals were observed for clinical signs once daily until the end of the observation period. All abnormalities were recorded.
Cageside observations included changes in the skin and fur, eyes and mucous membranes. Also respiratory, circulatory, autonomic and central nervous systems and somatomotor activity and behaviour pattern were examined. Particular attention was directed to observations of tremor, convulsions, salivation, diarrhoea, lethargy, sleep and coma.
Pathology:
At the end of the observation period the animals were sacrificed with an overdosage of pentobarbital injected intraperitoneally at a dosage of approx. 8 mL/kg bw.
All animals were subjected to gross necropsy. All gross pathological changes were recorded. - Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Remarks:
- LD50 cut off
- Effect level:
- 5 000 mg/kg bw
- Based on:
- test mat.
- Clinical signs:
- None of the animals showed weight loss during the observation period
No special gross pathological changes were recorded for any animal
The most relevant clinical findings in the animals treated with the test item at a dose of 2000 mg/kg bw were apathy, prone position, reduced spontaneous activity, wasp waist, hypertonia, ataxia, half eyelid closure, kyphosis, prostation. - Body weight:
- Animals no. 1-3, step 1: 158-164 g;
Animals no. 4-6, step 2: 163- 170 g; - Gross pathology:
- No special gross pathological changes were recorded for any animal
- Other findings:
- At necropsy, no macroscopical findings were observed in any animal of any step.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of the present study, single oral application of the test item 4-(Methacryloyloxy)benzophenone to rats at a dose of 2000 mg/kg body weight was associated with slight to severe signs of toxicity but no mortality.
The median lethal dose of 4-(Methacryloyloxy)benzophenone after a single oral administration to female rats, observed over a period of 14 days is: LD50 cut off (rat): 5000 mg/kg body weight.
In conformity with the criteria given in Annex VI to Commission Directive 2001/59/EC the test item 4-(Methacryloyloxy)benzophenone has no obligatory labelling requirement for toxicity.
According to Annex I of Regulation (EC) 1272/2008 the test item 4-(Methacryloyloxy)benzophenone is unclassified
According to OECD-GHS (Globally Harmonized Classification System) the test item 4-(Methacryloyloxy)benzophenone requires no obligatory labelling for toxicity - Executive summary:
4-(Methacryloyloxy)benzophenone was tested in an acute oral toxicity study ( (Acute Toxic Class Method) acc. OECD 423. Two groups, each of three female WIST AR Cr!: WI(Han) rats, were treated with the test item by oral gavage administration at a dosage of 2000 mg/kg body weight. The test item was suspended in a vehicle ( cottonseed oil) at a concentration of 0.2 g/mL and administered at a dose volume of 10 mL/kg.
All animals survived until the end of the study. The most relevant clinical findings in the animals treated with the test item at a dose of 2000 mg/kg bw were apathy, prone position, reduced spontaneous activity, wasp
waist, hypertonia, ataxia, half eyelid closure, kyphosis, prostation. Throughout the 14-day observation period, the weight gain of the animals was within the expected range. At necropsy, no macroscopical findings were observed in any animal of any step.
Under the conditions of the present study, single oral application of the test item 4-(Methacryloyloxy)benzophenone to rats at a dose of 2000 mg/kg body weight was associated with slight to severe signs of toxicity but no mortality.
The median lethal dose of 4-(Methacryloyloxy)benzophenone after a single oral administration to female rats, observed over a period of 14 days is: LD50 cut off (rat): 5000 mg/kg body weight.
In conformity with the criteria given in Annex VI to Commission Directive 2001/59/EC the test item 4-(Methacryloyloxy)benzophenone has no obligatory labelling requirement for toxicity.
According to Annex I of Regulation (EC) 1272/2008 the test item 4-(Methacryloyloxy)benzophenone is unclassified:
According to OECD-GHS (Globally Harmonized Classification System) the test item 4-(Methacryloyloxy)benzophenone requires no obligatory labelling for toxicity
Reference
LD50 cut off
Dose (unit) |
Number of animals investigated |
Number of intercurrent deaths |
LD50cutoff |
2000mg/kg bodyweight |
6 |
0 |
5000mg/kg body weight |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
In conformity with the criteria given in Annex VI to Commission Directive 2001/59/EC the test item 4-(Methacryloyloxy)benzophenone has no obligatory labelling requirement for toxicity.
According to Annex I of Regulation (EC) 1272/2008 the test item 4-(Methacryloyloxy)benzophenone is unclassified:
According to OECD-GHS (Globally Harmonized Classification System) the test item 4-(Methacryloyloxy)benzophenone requires no obligatory labelling for toxicity
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